Table 4.
Cytotoxicity of P. domestica samples extracted under acidic and neutral conditions for gastric (AGS) and colon (SW-620) carcinoma cells, as well non-tumoral cells (Vero).
| Sample | AGS | SW620 | Vero |
| IC50 (μg/mL) 1,2 (SI) 3 | |||
| Acid Extraction | |||
| Methley | |||
| Skin | 403 a,* ± 13 (1.2) | 318 a,# ± 5 (1.6) | >500 a,& |
| Flesh | 196 b,* ± 9 (2.6) | 161 b,# ± 5 (3.1) | >500 a,& |
| Pisardii | |||
| Skin | >500c | >500 c | >500 a |
| Flesh | >500 c,* | 387 d,# ± 24 (1.3) | >500 a,* |
| Satsuma | |||
| Skin | 340 d,* ± 29 (1.5) | 255 e,# ± 16 (2.0) | >500 a,& |
| Flesh | >500 c | >500 c | >500 a |
| AGS | SW620 | Vero | |
| IC50 (μg/mL) 1,2 (SI) 3 | |||
| Neutral Extraction | |||
| Methley | |||
| Skin | 186 a,* ± 7 (2.7) | 122 a,# ± 7 (4.1) | >500 a,& |
| Flesh | 76.3 b,* ± 6.8 (6.6) | 60.9 bc,* ± 4.1 (8.2) | >500 a,# |
| Pisardii | |||
| Skin | 83.1 b,* ± 5.2 (6.0) | 67.9 b,# ± 2.4 (7.4) | >500 a,& |
| Flesh | 125 c,* ± 10 (4.0) | 132 a,* ± 3 (3.8) | >500 a,# |
| Satsuma | |||
| Skin | 60.7 b,* ± 4.6 (6.2) | 46.7 c,* ± 1.5 (8.1) | 378 b,# ± 33 |
| Flesh | 75.0 b,* ± 5.1 (6.6) | 73.0 b,* ± 4.1 (6.8) | >500 a,# |
1 Values are expressed as the mean ± D.E. 2 Different superscript letters in the same column or different superscript signs in the same row indicate that the IC50 differences are significant at p < 0.05 using a one-way analysis of variance (ANOVA) with a Tukey post hoc statistical test. 3 (SI) = Selectivity Index.