Table 2.

Properties of selected neutral cannabinoids.

	Compound Name (Acronym)	Potential Health Benefits	Psychoactive Effects on the Human Body	Cannabis sativa L. Variety in Which the Compound Is Present at Relatively High Concentrations	Use (Medicine, Dietary Supplements, Food)	Effects on the Endocannabinoid System	References
Non-psychoactive cannabinoids	Cannabigerol (CBG)	Antineoplastic	None demonstrated	All varieties	Food, medicine	Low affinity to the CB1 and CB2 receptors, and shows an ability to inhibit anandamide uptake	[16,27,32,43,44]
	Cannabichromen (CBC)	Antidepressant	None demonstrated	All varieties	Medicine	-	[27,32]
	Cannabidiol (CBD)	Analgesic, anti-inflammatory, anxiolytic, and antineoplastic	None demonstrated	All varieties, but mainly in Cannabis sativa L. var. sativa	Dietary supplements, food	Weak antagonistic action against the CB1 and CB2 receptors, and eliminates the effects of Δ9-THC	[31,44,45,46,47,48]
	Δ9-Tetrahydrocannabivarin (Δ9-THCV),	Treatment of obesity and epilepsy	None demonstrated	All varieties, but mainly in Cannabis sativa L. var. sativa	Medicine	Partial agonist of the CB2 receptors and antagonist of the CB1 receptors	[49,50]
Psychoactive cannabinoids	Δ9-Tetrahydrocannabinol (Δ9-THC)	Improves sleep and stimulates appetite in cancer patients	Demonstrated	All varieties, but mainly in Cannabis sativa L. var. indica	Medicine	Binds and activates the CB1 receptors	[31,51,52,53]
	Δ8-Tetrahydrocannabinol (Δ8-THC)	Anti-glaucoma, and supports the treatment of damaged epithelium of the cornea	Demonstrated, but weaker than Δ9-THC	All varieties, but mainly in Cannabis sativa L. var. indica	Medicine	Binds and activates the CB1 receptors	[54,55]
	Cannabinol (CBN)		Demonstrated, but 10× weaker than Δ9-THC	All varieties	-	Binds cannabinoid receptors, showing higher affinity to the CB2 receptors and weak agonism to the CB1 receptors	[25,44]