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Crystal structure of CA VII and CA XIV in complex with ACZ. (A) The ACZ chelates, together with the three conserved His, Zn2+ in the catalytic site of CA VII. Hydrophobic residues are colored in yellow, while hydrophilic residues are colored in blue (pdb 3ML5). (B) The ACZ chelates, together with the three conserved His, Zn2+ in the catalytic site of CA XIV. Hydrophobic residues are colored in red, while hydrophilic residues are colored in blue (pdb 4LU3).
