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. 2021 Nov 12;19:277. doi: 10.1186/s12916-021-02138-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Kaplan–Meier survival curve analysis for enrolled glioma patients. A Kaplan-Meier survival curve for OS and DFS of preoperative CTCs. p=0.12 and p=0.19, respectively. There were no statistical differences between the two groups. B OS and DFS of postoperative CTCs. p< 0.0001 and p=0.0011, respectively. There were significant differences between the two groups. C OS and DFS of the high-grade group preoperative CTCs. p=0.63 and p=0.55, respectively. There were no statistical differences between the two groups. D OS and DFS of the low-grade group preoperative CTCs. p=0.11 and p=0.32, respectively. There were no statistical differences between the two groups. E. OS and DFS of the high-grade group postoperative CTCs. p=0.0022 and p=0.0034, respectively. There were significant differences between the two groups. F OS and DFS of the low-grade group postoperative CTCs. p=0.0025 and p=0.0048, respectively. There were significant differences between the two groups. Red, CTC-negative group; Blue, CTC-positive group. p < 0.05 was considered significant, and the 95% CI is shown as a red or blue shadow