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. 2021 Nov 12;19:277. doi: 10.1186/s12916-021-02138-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Correlation between postoperative CTCs and clinical blood examination data. A. The proportions of lymphocytes, monocytes, and neutrophils between the CTC-negative group and the CTC-positive group. ns, no significant difference, ****, p< 0.0001. B The correlation between CTCs and the proportion of lymphocytes. Pearson r=− 0.62, p< 0.0001. C The correlation between CTCs and the proportion of neutrophils. Pearson r = 0.64, p < 0.0001. D The correlation between CTCs and the proportion of monocytes. Pearson r = − 0.18, p=0.11. E–G. Correlation heatmap of CTCs and clinical blood examination data in all patients, CTC-positive patients, and CTC-negative patients. Positive correlations are shown in cool colors, while negative correlations (anticorrelations) are shown in hot colors. H Cell components of peripheral blood immune cells in the CTC-positive group and CTC-negative group evaluated by EPIC. I The proportions of monocytes, B cells, and NK cells between the CTC-negative group and the CTC-positive group. ns, no significant difference, **, p< 0.01. J The proportions of CD4 T cells, CD8 T cells, and neutrophils between the CTC-negative group and the CTC-positive group. *, p< 0.05; ****, p< 0.001