Table 1.
Demographics of FEDN, chronic patients with schizophrenia and healthy controls
| FEDN patients (n = 51) | Chronic patients (n = 52) | Healthy controls (n = 114) | F or T or Zor X2 | P-value | |
|---|---|---|---|---|---|
| Sex, male/female | 32/19 | 45/7 | 21/93 | 75.229 | < 0.001 |
| Age (years) | 27.51 ± 8.71 | 47.6 ± 4.40 | 44.31 ± 14.40 | 48.521 | < 0.001 |
| Education (years) | 11.84 ± 3.57 | 9.40 ± 2.04 | 8.49 ± 3.96 | 16.133 | < 0.001 |
| Age of onset (years) | 25.63 ± 9.12 | 23.92 ± 5.94 | 1.122 | 0.265 | |
| Duration of illness (months) | 18 (6,36) | 284.08 ± 83.23 | −8.749 | < 0.001a | |
| BMI (kg/m2) | 22.5 ± 3.80 | 23.56 ± 4.26 | −1.140 | 0.256 | |
| Antipsychotic dose (mg/day) (chlozapine equivalents) | 375 (262,500) | ||||
| PANSS total score | 86.71 ± 20.39 | 76.81 ± 18.28 | 2.595 | 0.011 | |
| Positive subscore | 26.33 ± 6.13 | 16.42 ± 6.17 | 8.175 | < 0.001 | |
| Negative subscore | 18.94 ± 7.49 | 24.71 ± 6.33 | −4.224 | < 0.001 | |
| General psychopathology subscore | 41.43 ± 12.59 | 35.67 ± 10.12 | 2.561 | 0.012 | |
| TNF-α (pg/ml) | 19 (9.86,34.33) | 10.24 ± 2.14 |
1.98 (0.00,26.34) |
< 0.001* |
Note: FEDN, first-episode drug-naïve; PANSS, Positive and Negative Syndrome Scale; TNF-α, tumor necrosis factor-α. a Mann-Whitney U test, * Kruskal-Wallis H test