Table 3.
A summary overview of cancers in which sperm associated antigens (SPAGs) are involved
|
| |
|---|---|
| SPAG | Cancer type |
|
| |
| SPAG1 | Pancreatic tumorigenesis (55), Renal cancer, Seminoma, Colon cancer, Breast cancer (2) |
| SPAG2/UAP1 | Prostate cancer (56), Lymphoma, Renal cancers (2) |
| SPAG3/HSPA2 | Pancreatic tumorigenesis (57) |
| SPAG4 | Lung cancer, Kidney cancer (58), Prostate cancer, Liver cancer, Breast cancer (2) |
| SPAG5 | Urothelial cancer (59), Breast cancer (2, 60), Lung cancer (61, 62), Gastric cancer (61), Hepatocellular carcinoma (63), Bladder cancer (2) |
| SPAG6 | Myelodysplastic syndrome (24), Spinal cord neoplasm, Prostate cancer, Colon cancer (2) |
| SPAG7 | Brain cancer, Synovial sarcoma, Prostate cancers (2) |
| SPAG8 | Lung cancer, Breast cancer, Cervical carcinoma (2) |
| SPAG9 | Thyroid cancer, Hepatocellular carcinoma, Renal cell carcinoma, Gastric cancer, Endometrial carcinoma, Lung cancer, Osteosarcoma, Breast cancer, Cervical cancers, Acute myeloid leukemia, Ovarian cancer (34), Brain cancer (2) |
| SPAG10/MFGE8 | Breast cancer, Colorectal cancer (40) |
| SPAG11B | Testicular seminoma, Breast cancer (2) |
| SPAG12/SNU13/ NHP2L1 | Bladder cancer, Renal carcinoma (2) |
| SPAG13/KRAP/SSFA2 | Brain cancer, Colorectal cancer, Esophagus cancer (2), Lung adenocarcinoma (64), Oral squamous cell carcinoma (65) |
| SPAG15/SPAM1 | Breast cancer (66), Laryngeal carcinoma, Brain cancer, Colon cancer, Lung carcinoma, Melanoma (2) |
| SPAG16 | Urothelial cancer, Breast cancer (2) |
| SPAG17 | Pancreatic cancer, Brain cancer (2) |
| SPAG18/PSMA5 | Colorectal cancer cell lines, Chromophobe renal cell adenocarcinoma, Gastric cancer, Bladder cancer, Lung carcinoma, Head and neck cancer, Melanoma, Pulmonary neuroendocrine tumor (67) |
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| |