Table II.

Summary of pooled estimates for all meta-analyses undertaken, by definition of anaphylaxis used

Indicator	Trigger, % of reactions treated with >1 dose of epinephrine
	All		Food			Venom
	Any setting (n = 36,557)	Community (n = 34,121)	Any setting (n = 12,615)	Community (n = 10,179)	Food challenge (n = 2,436)	Any setting (n = 3,194)
Study-defined anaphylaxis	7.7% (6.4%-9.1%)	7.9% (6.5%-9.7%)	7.3% (5.8%-9.1%)	7.7% (6.5%-10.0%)	6.5% (4.2%-9.8%)	10.5% (6.2%-17.1%)
Cardiorespiratory anaphylaxis	9.8% (7.8%-12.2%)	9.6% (7.6%-12.1%)	9.7% (7.0%-13.4%)	9.1% (6.2%-13.1%)	10.8% (6.0%-18.8%)	11.1% (4.3%-26.0%)
Reaction treated with ≥1 dose of epinephrine	12.9% (11.2%-14.9%)	13.5% (11.5%-15.9%)	11.7% (9.9%-13.9%)	12.3% (9.9%-15.2%)	10.6% (7.9%-14.1%)	17.9% (13.2%-24.0%)
Reaction for which further epinephrine was administered by a health care professional	7.1% (5.8%-8.7%)	7.2% (5.7%-9.0%)	7.0% (5.5%-8.9%)	7.1% (5.3%-9.5%)	6.8% (4.4%-10.4%)	10.0% (5.1%-18.8%)
Epinephrine-treated reaction for which further epinephrine was administered by a health care professional	12.2% (10.4%-14.3%)	12.8% (10.6%-15.4%)	11.1% (9.4%-13.2%)	11.4% (9.1%-14.0%)	10.8% (8.0%-14.4%)	17.1% (11.3%-25.0%)

Further subgrouping of meta-analyses by reaction trigger (any trigger, food, or venom) and setting (community reactions, food challenges under medical supervision, or any setting) are listed. Data are presented as percentages (pooled estimates [95% CI]).