Table III.
Total number of epinephrine doses given to individual patients receiving multiple doses of epinephrine
| Study | % with food trigger | Proportion of anaphylaxis reactions treated with epinephrine |
Proportion of epinephrine-treated reactions treated with multiple doses of epinephrine |
|||||
|---|---|---|---|---|---|---|---|---|
| 1 Dose (%) | 2 Doses (%) | 3 Doses (%) | ≥4 Doses (%) | 2 Doses (%) | 3 Doses (%) | ≥4 Doses (%) | ||
| Järvinen et al, 200849 | 100% | 77/95 (81%) | 12/95 (13%) | 6/95 (6.3%) | 0/95 (0%) | 12/95 (13%) | 6/95 (6.3%) | 0/95 (0%) |
| Manivannan et al, 200910 | 33% | 77/208 (37%) | 25/208 (12%) | 2/208 (1.0%) | 0/208 (0%) | 25/104 (24%) | 2/104 (1.9%) | 0/104 (0%) |
| Noimark et al, 201276 | 91% | 28/245 (11%) | 12/245 (4.9%) | 1/245 (0.4%) | 0/245 (0%) | 12/41 (29%) | 1/41 (2.4%) | 0/41 (0%) |
| Brown et al, 201340 | 36% | 130/315 (54%) | 59/315 (19%) | 39/315 (12%) | 17/315 (5.4%) | 59/245 (24%) | 39/245 (16%) | 17/245 (6.9%) |
| Campbell et al, 201513 | 36% | 281/582 (48%) | 36/582 (6.2%) | 6/582 (1.0%) | 3/582 (0.5%) | 36/326 (11%) | 6/326 (1.8%) | 3/326 (0.9%) |
| Nogic et al, 201672 | 75% | 38/52 (73%) | 10/52 (19%) | 1/52 (1.9%) | 0/52 (0%) | 10/49 (20%) | 1/49 (2.0%) | 0/49 (0%) |
| Yanagida et al, 201722 | 100% | 70/190 (37%) | 18/190 (9.5%) | 2/190 (1.1%) | 0/190 (0%) | 18/90 (20%) | 2/90 (2.2%) | 0/90 (0%) |
| Tsuang et al, 201814 | 100% | 197/221 (89%) | 19/221 (8.6%) | 4/221 (1.8%) | 1/221 (0.5%) | 19/221 (8.6%) | 4/221 (1.8%) | 1/221 (0.5%) |
| Anvari et al, 201921 | 48% | 218/275 (79%) | 20/275 (7.3%) | 5/275∗ (1.8%) | — | 20/243 (8.2%) | 5/243∗ (2.1%) | — |
| Gabrielli et al, 201987 | 79% | 2276/3498 (65%) | 234/3498 (6.7%) | 36/3498 (1.0%) | 12/3498 (0.3%) | 234/2558 (9.1%) | 36/2558 (1.4%) | 12/2558 (0.5%) |
| Liu et al, 201984 | 38% | 255/430 (59%) | 34/430 (7.9%) | 16/430∗ (3.7%) | — | 34/305 (11%) | 16/305∗ (5.2%) | — |
| Pooled estimate at meta-analysis (95% CI) | 57% (41%-72%) | 9.2% (7.2%-12%) | 2.2% (1.1%-4.1%) | 14% (11%-19%) | 3.4% (1.9%-5.9%) | |||
| 1.9% (1.0%-3.5%) | 0.3% (0.1%-1.3%) | 2.9% (1.7%-5.0%) | 0.5% (0.1%-1.9%) | |||||
These data were available in 11 studies. The pooled estimate for each dosing bracket is provided as a percentage of either the total number of study-defined anaphylaxis reactions or epinephrine-treated reactions (95% CI).
∗
Data available only for 3 or more doses.