Table 2.
Plasma level of molecules involved in bone remodeling in the population characterized into 4 groups: non-diabetic non obese (ND-Nob), non-diabetic obese (ND-ob), type 2 diabetes non obese (T2D-Nob) and type 2 diabetes obese (T2D-ob).
| Osteogenic Factors | ND (n = 124) | T2D (n = 104) | Anova | Tukey Multiple comparisons | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nob | ob | Nob | ob | ND-Nob | ND-ob | T2D-Nob | |||||
| (n = 73) | (n = 51) | (n = 38) | (n = 66) | Overall p | ND-ob | T2D-Nob | T2D-ob | T2D-Nob | T2D-ob | T2D-ob | |
| Osteoactivin (ng/ml) | 16.036 ± 0.358 | 17.363 ± 0.499 | 19.54 ± 1.067 | 21.210 ± 0.691 | <0.0001 | 0.0472 | <0.0001 | <0.0001 | 0.0127 | <0.0001 | 0.2754 |
| OPG (pg/ml) | 696.90 ± 20.57 | 768.82 ± 29.70 | 912.80 ± 45.88 | 1034.330 ± 44.27 | <0.0001 | 0.0362 | <0.0001 | <0.0001 | 0.1905 | <0.0001 | 0.2966 |
| SPARC (ng/ml) | 795.04 ± 71.33 | 834.00 ± 64.65 | 1331.61 ± 74.49 | 957.920 ± 133.71 | 0.0385 | 0.9734 | 0.0432 | 0.3195 | 0.1433 | 0.6272 | 0.7342 |
| Syndecan-4 (pg/ml) | 1680.65 ± 79.69 | 1842.31 ± 02.01 | 2256.03 ± 43.08 | 1972.03 ± 129.43 | 0.0043 | 0.6909 | 0.0092 | 0.0398 | 0.1492 | 0.4621 | 0.8353 |
Data are presented as mean ± SEM. One-way ANOVA test was used to compare the level of various osteogenic molecules across different groups. Tukey post-hoc analysis was performed to compare the groups.
Bold values indicate statistically significant results.