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. 2021 Oct 29;12:746647. doi: 10.3389/fimmu.2021.746647

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Copyright © 2021 Liu, Chen, Wang, Qian, Wei, Xing and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The m1A modification patterns in OC and biological characteristics of m1A subtypes. (A) The principal component analysis for the transcriptome profiles of three m1A modification patterns. (B) Survival analyses of the three m1A modification patterns based on 611 OC patients. (C) Unsupervised clustering of 10 m1A regulators in two independent ovarian cancer cohorts. (D, E) GSVA enrichment analysis showing the activation states of biological pathways in distinct m1A modification patterns. The red represented activated pathways and blue represented inhibited pathways. (D) The m1A cluster A vs m1A cluster B; (E) The m1A cluster B vs m1A cluster C.