Table 3.
Ordinary least squares multiple regression models predicting perceived stress scores at follow-up in a sample of sexual and gender minority youth in the RADAR cohort study
| Inflammation Index Model | IL-1β Model | TNFα Model | IL-6 Model | CRP Model | |
|---|---|---|---|---|---|
| Coefficient (SE) | Coefficient (SE) | Coefficient (SE) | Coefficient (SE) | Coefficient (SE) | |
| Inflammation | −0.047 | ||||
| (0.048) | |||||
| IL-1β | 0.002 | ||||
| (0.052) | |||||
| TNFα | −0.001 | ||||
| (0.045) | |||||
| IL-6 | −0.038 | ||||
| (0.044) | |||||
| CRP | −0.080* | ||||
| (0.044) | |||||
| Incident Trauma | 0.213** | 0.209** | 0.196** | 0.224*** | 0.218*** |
| (0.083) | (0.084) | (0.084) | (0.084) | (0.084) | |
| Baseline Depression Score | 0.515*** | 0.515*** | 0.513*** | 0.518*** | 0.523*** |
| (0.036) | (0.036) | (0.036) | (0.037) | (0.037) | |
| HIV Positive | −0.107 | −0.120 | −0.100 | −0.064 | −0.051 |
| (0.101) | (0.107) | (0.097) | (0.092) | (0.095) | |
| Body Mass Index | 0.002 | −0.001 | 0.004 | 0.005 | 0.017 |
| (0.039) | (0.037) | (0.037) | (0.039) | (0.039) | |
| Age | 0.051 | 0.043 | 0.043 | 0.050 | 0.050 |
| (0.041) | (0.041) | (0.041) | (0.041) | (0.041) | |
| Gender (ref=Man) | |||||
| Woman | 0.050 | 0.027 | 0.047 | 0.059 | 0.062 |
| (0.145) | (0.146) | (0.145) | (0.145) | (0.145) | |
| Non-binary | −0.099 | −0.139 | −0.039 | −0.157 | −0.149 |
| (0.298) | (0.299) | (0.302) | (0.299) | (0.299) | |
| Race/ethnicity (ref=Black/African American) | |||||
| Hispanic/Latinx | 0.080 | 0.066 | 0.078 | 0.073 | 0.083 |
| (0.091) | (0.092) | (0.092) | (0.092) | (0.092) | |
| White | 0.283*** | 0.275** | 0.282** | 0.281** | 0.281** |
| (0.109) | (0.109) | (0.109) | (0.110) | (0.109) | |
| Other | −0.039 | −0.083 | −0.050 | −0.058 | −0.033 |
| (0.174) | (0.175) | (0.175) | (0.175) | (0.176) | |
| CUDIT-R Score | 0.009 | 0.006 | 0.002 | 0.008 | 0.009 |
| (0.040) | (0.041) | (0.041) | (0.040) | (0.041) | |
| Cigarette Use (ref=Never) | |||||
| Once or twice | −0.031 | −0.019 | −0.015 | −0.024 | −0.036 |
| (0.109) | (0.109) | (0.109) | (0.109) | (0.109) | |
| Occasionally | −0.021 | −0.010 | −0.023 | −0.010 | 0.005 |
| (0.120) | (0.120) | (0.120) | (0.120) | (0.121) | |
| Regularly in the past | −0.223 | −0.228 | −0.221 | −0.224 | −0.225 |
| (0.150) | (0.151) | (0.151) | (0.151) | (0.151) | |
| Regularly now | −0.055 | −0.050 | −0.035 | −0.036 | −0.042 |
| (0.118) | (0.118) | (0.117) | (0.118) | (0.118) | |
| E-cigarette use (ref=never) | |||||
| Once or twice | 0.045 | 0.041 | 0.030 | 0.052 | 0.042 |
| (0.089) | (0.089) | (0.090) | (0.090) | (0.090) | |
| Occasionally | 0.057 | 0.059 | 0.076 | 0.081 | 0.068 |
| (0.135) | (0.136) | (0.135) | (0.135) | (0.136) | |
| Regularly in the past | 0.031 | −0.018 | −0.046 | −0.005 | 0.008 |
| (0.298) | (0.298) | (0.298) | (0.298) | (0.304) | |
| Regularly now | 0.174 | 0.224 | 0.177 | 0.203 | 0.178 |
| (0.257) | (0.258) | (0.258) | (0.258) | (0.258) | |
| Inflammation*Incident Trauma | 0.243*** | ||||
| (0.083) | |||||
| IL-1β*Incident Trauma | 0.147* | ||||
| (0.079) | |||||
| TNFα*Incident Trauma | 0.197** | ||||
| (0.093) | |||||
| IL-6*Incident Trauma | 0.186** | ||||
| (0.090) | |||||
| CRP*Incident Trauma | 0.161* | ||||
| (0.082) | |||||
| Intercept | −0.115 | −0.101 | −0.116 | −0.129 | −0.131 |
| (0.085) | (0.087) | (0.085) | (0.085) | (0.085) | |
|
| |||||
| Observations | 517 | 518 | 518 | 518 | 517 |
| R2 | 0.336 | 0.330 | 0.331 | 0.330 | 0.331 |
Note:
*
p<0.1
**
p<0.05
***
p<0.01
Inflammation = Combined inflammatory index
IL-1β = natural log-transformed interleukin-1β
TNFα = natural log-transformed plasma tumor necrosis factor-α values
IL-6 = natural log-transformed plasma interleukin-6 values
CRP = natural log-transformed plasma C-reactive protein values
Numeric variables are standardized to produce β coefficients