Table 1.
Full list of experimental methods and results
| Reaction number | Co-former molecules | Experimental conditions | Product obtained |
|---|---|---|---|
| 1 | ASA | 0.1 mM/acetonitrile/aa | Needle crystals |
| 2 | ASA | 0.2 mM/acetonitrile/aa | Needle crystals |
| 3 | ASA | 0.1 mM/ethanol/aa | Plate crystals |
| 4 | ASA | 0.2 mM/ethanol/aa | Plate crystals |
| 5 | ASA | 0.1 mM/methanol/aa | Plate crystals |
| 6 | ASA | 0.2 mM/methanol/aa | Plate crystals |
| 7 | ASA | 0.1 mM/ethyl acetate/aa | No crystal observed |
| 8 | ASA | 0.2 mM/ethyl acetate/aa | No crystal observed |
| 9 | ASA | 0.1 mM/isopropanol/aa | Needle shape crystals |
| 10 | ASA | 0.2 mM/isopropanol/aa | Needle shape crystals |
| 11 | ASA | 1:1/acetonitrile/RT/se | No crystal observed |
| 12 | ASA | 1:2/acetonitrile/RT/se | No crystal observed |
| 13 | ASA | 1:3/acetonitrile/RT/se | No crystal observed |
| 14 | ASA | 1:1/ethanol/RT/se | No crystal observed |
| 15 | ASA | 1:2/ethanol/RT/se | No crystal observed |
| 16 | ASA | 1:3/ethanol/RT/se | No crystal observed |
| 17 | ASA | 1:1/methanol/RT/se | No crystal observed |
| 18 | ASA | 1:2/methanol/RT/se | No crystal observed |
| 19 | ASA | 1:3/methanol/RT/se | No crystal observed |
| 20 | ASA | 1:1/acetone/RT/se | Irregular crystals |
| 21 | ASA | 1:2/acetone/RT/se | Irregular crystals |
| 22 | ASA | 1:3/acetone/RT/se | Irregular crystals |
| 23 | ASA | 1:1/ethyl acetate/RT/se | Irregular crystals |
| 24 | ASA | 1:2/ethyl acetate/RT/se | Irregular crystals |
| 25 | ASA | 1:3/ethyl acetate/RT/se | Irregular crystals |
| 26 | FMA | 0.001 mM/ethyl acetate/aa | No crystal observed |
| 27 | FMA | 0.002 mM/ethyl acetate/aa | No crystal observed |
| 28 | FMA | 0.003 mM/ethyl acetate/aa | No crystal observed |
| 29 | FMA | 0.002 mM/acetone/aa | No crystal observed |
| 30 | FMA | 0.0032 mM/acetone/aa | No crystal observed |
| 31 | FMA | 0.0048 mM/acetone/aa | No crystal observed |
| 32 | FMA | 1:1/acetonitrile, se | No crystal observed |
| 33 | FMA | 1:2/acetonitrile, se | No crystal observed |
| 34 | FMA | 1:3/acetonitrile, se | No crystal observed |
| 35 | FMA | 1:1/ethanol, se | No crystal observed |
| 36 | FMA | 1:2/ethanol, se | No crystal observed |
| 37 | FMA | 1:3/ethanol, se | No crystal observed |
| 38 | FMA | 1:1/methanol, se | No crystal observed |
| 39 | FMA | 1:2/methanol, se | No crystal observed |
| 40 | FMA | 1:3/methanol, se | No crystal observed |
| 41 | FMA | 1:1/acetone, se | Irregular crystals |
| 42 | FMA | 1:2/acetone, se | Irregular crystals |
| 43 | FMA | 1:3/acetone, se | Irregular crystals |
| 44 | FMA | 1:1/ethyl acetate, se | Irregular crystals |
| 45 | FMA | 1:2/ethyl acetate, se | Irregular crystals |
| 46 | FMA | 1:3/ethyl acetate, se | Irregular crystals |
| 47 | BZA | 1:1/acetonitrile, se | No crystal observed |
| 48 | BZA | 1:2/acetonitrile, se | No crystal observed |
| 49 | BZA | 1:3/acetonitrile, se | No crystal observed |
| 50 | BZA | 1:1/ethanol, se | No crystal observed |
| 51 | BZA | 1:2/ethanol, se | No crystal observed |
| 52 | BZA | 1:3/ethanol, se | No crystal observed |
| 53 | BZA | 1:1/methanol, se | No crystal observed |
| 54 | BZA | 1:2/methanol, se | No crystal observed |
| 55 | BZA | 1:3/methanol, se | No crystal observed |
| 56 | BZA | 1:1/acetone, se | Irregular crystals |
| 57 | BZA | 1:2/acetone, se | Irregular crystals |
| 58 | BZA | 1:3/acetone, se | Irregular crystals |
| 59 | BZA | 1:1/ethyl acetate, se | Irregular crystals |
| 60 | BZA | 1:2/ethyl acetate, se | Irregular crystals |
| 61 | BZA | 1:3/ethyl acetate, se | Irregular crystals |
aa=Antisolvent addition method. se=Slow solvent evaporation method, RT=Room temperature (25°C–32°C), ASA: Acetylsalicylic acid or aspirin, FMA: Fumaric acid, BZA: Benzoic acid