Table 3.

Participant timeline

	Study period
	Enrolment	Allocationa	Monitoring during treatment		End of treatment	Follow-up since randomization (months)
Study phase	Admission to randomization		Weekly	Bi-weekly		3	6	12b
Enrolment
Eligibility screen	✓
Informed consent	✓
Cranial imaging	− 3 to 0 days
Allocation		✓
Intervention		●-------------------------------------------------------------●
Assessments
E-GOS					✓	✓	✓	✓
Clinical examination		✓	✓		✓	✓	✓	✓
Cranial imaging				✓	✓	✓	✓
Morisky scores (oral arm)			✓
Blood tests		✓	✓		✓	✓	✓
SF-36 + EQ-5D-5L + MoCA		✓			✓	✓	✓	✓
Screening for immunodeficiency		✓					✓

E-GOS Extended Glasgow Outcome Scale score. Blood tests include c-reactive protein, complete blood count, creatinine, liver function tests

^aAfter 14 days or longer since definitive neurosurgical treatment or IV antibiotic therapy for brain abscess

^bCan be replaced by telephone consultation