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TbKIFC1 downregulation confers more sensitivity to antibody-mediated lysis.
The cholesterol-trafficking activity of TbKIFC1 contributes to high plasma membrane fluidity, conferring resistance to IgM-mediated killing through efficient clearance of VSG-antibody complexes from the parasite surface [30••]. Following TbKIFC1 RNAi, trypanosomes are lyzed due to slower clearance of antibody-VSG complexes from the surface.
