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. 2021 Oct 29;12:757088. doi: 10.3389/fendo.2021.757088

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Copyright © 2021 Sun, Zou, Li, Xu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of risk score for PDR using the least absolute shrinkage and selection operator regularization (LASSO-LR) model. (A) Dotted vertical lines were drawn at the optimal values with Lambda (log), by using the minimum criteria and the 1 standard error of the minimum criteria (the 1-SE criteria). (B) Statistical analysis of pseudouridine, glutamate, leucylleucine and N-acetyltryptophan between PDR and not-PDR group (^**p < 0.01; ^***p < 0.001; ^****p < 0.0001). (C) Distribution of the risk score in the group. (D) Statistical analysis for distribution of risk score between PDR and not-PDR group (^****p < 0.0001). (E) ROC curves were created to evaluate the power of risk score. (F) A linear correlation analysis between risk score and HbA1c levels.