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. 2021 Sep 30;14(11):e008532. doi: 10.1161/CIRCHEARTFAILURE.121.008532

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© 2021 The Authors.

Circulation: Heart Failure is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Mass spectrometry revealed differential regulation of proteins involved in protein quality control in hearts of PLN-R14^Δ/Δ mice. A, Principal component (PC) analysis plot of mass spectrometry results of 3-, 5-, and 8-wk-old WT (wild-type; circles), PLN-R14^Δ/+ (diamonds), and PLN-R14^Δ/Δ (squares) mice (n=6 per group, except n=5 for 8-wk-old WT mice, all male). B and C, Venn diagrams of significantly upregulated (B) and downregulated (C) proteins in 3-, 5-, and 8-wk-old PLN-R14^Δ/Δ mice as compared with age-matched WT mice. D, Top 10 most significantly upregulated and downregulated gene ontology biological processes in 3-, 5-, and 8-wk-old PLN-R14^Δ/Δ mice as compared with age-matched WT mice. An overview of the enrichment data can be found in Tables VII through IX in the Data Supplement. MHC indicates myosin heavy chain; n.s., not significant; P_adj, adjusted P; and TAP, transporter associated with antigen processing.