Table 1. Mutations identified in the SARS-CoV-2 genome of Utah mink isolates.
SNPs and nonsynonymous mutations identified. Amino acid (AA) and codon numbering is relative to Wuhan-Hu-1. Percentages of non-synonomous mutations found in Neovison vision data from 955 GISAID whole genome sequences is indicated. * = mutations unique to this study.
| Gene | Mutation Farm A | Mutation Farm B | Mutation Farm C | Mutation type | % found in mink |
|---|---|---|---|---|---|
| NSP2 | T85I | T85I | T85I | AA substitution | 12.1% |
| NSP3 | S1206L | S1206L | S1206L | AA substitution | 0.8%* |
| NSP9 | G37E | G37E | G37E | AA substitution | 19.5% |
| NSP12 | P323L | P323L | P323L | AA substitution | 95.4% |
| NSP13 | V187I | AA substitution | 0.2%* | ||
| NSP16 | T91M | T91M | T91M | AA substitution | 0.8%* |
| Spike | N501T | N501T | N501T | AA substitution | 12.3% |
| Spike | D614G | D614G | D614G | AA substitution | 95.4% |
| Spike | K113T | AA substitution | 0.2%* | ||
| NS3 | Q57H | Q57H | Q57H | AA substitution | 18.7% |
| NS3 | H182Y | H182Y | H182Y | AA substitution | 69.1% |
| M | A38S | AA substitution | 0.4%* | ||
| N | T205I | T205I | AA substitution | 0.8%* | |
| N | Q289H (1 of 2) | Q289H | AA substitution | 0.5%* |