Table 1. Demographic and clinical characteristics of individuals with confirmed COVID-19 infection and effect on disease severity (defined as mild or moderate-to-severe according to hospital admission and mortality).
| Characteristics | All (n = 68,913) | P value | Women (n = 36,682) | P value | Men (n = 32,231) | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Milda (x = 63,028) | Moderate-to-severeb | ORc (95% CId) | Mild | Moderate-to-severe (n = 2778) | OR (95% CI) | Mild | Moderate-to-severe | OR (95% CI) | ||||
| (n = 5885) | (n = 33,904) | (n = 29,124) | (n = 3107) | |||||||||
| Sex, men (n, %) | 29,124 (46.2) | 3107 (52.8) | 1.71 (1.61–1.82) | <0.001 | - | - | - | - | - | - | - | - |
| Age (mean, sde) | 41.9 (22.7) | 71.6 (18.7) | 1.07 (1.06–1.07) | <0.001 | 43.3 (23.3) | 73.9 (19.2) | 1.06 (1.06–1.06) | <0.001 | 40.3 (21.9) | 69.6 (18.0) | 1.07 (1.07–1.07) | <0.001 |
| Age intervals (n, %) | ||||||||||||
| ≤14 | 8075 (12.8) | 47 (0.80) | 0.07 (0.06–0.10) | <0.001 | 4020 (11.9) | 16 (0.58) | 0.07 (0.04–0.12) | <0.001 | 4055 (13.9) | 31 (1.00) | 0.07 (0.05–0.10) | <0.001 |
| 15–44 | 26,367 (41.8) | 469 (7.97) | 0.23 (0.21–0.25) | <0.001 | 13,902 (41.0) | 234 (8.42) | 0.31 (0.27–0.37) | <0.001 | 12,465 (42.8) | 235 (7.56) | 0.18 (0.16–0.21) | <0.001 |
| 45–64 | 18,358 (29.1) | 1422 (24.2) | Reference | - | 9844 (29.0) | 530 (19.1) | Reference | - | 8514 (29.2) | 892 (28.7) | Reference | - |
| 65–79 | 5905 (9.37) | 1427 (24.2) | 3.11 (2.88–3.37) | <0.001 | 3118 (9.20) | 579 (20.8) | 3.45 (3.05–3.91) | <0.001 | 2787 (9.57) | 848 (27.3) | 2.90 (2.62–3.22) | <0.001 |
| ≥80 | 4323 (6.86) | 2520 (42.8) | 8.23 (7.64–8.87) | <0.001 | 3020 (8.91) | 1419 (51.1) | 8.73 (7.84–9.72) | <0.001 | 1303 (4.47) | 1101 (35.4) | 8.07 (7.26–8.97) | <0.001 |
| Rural areaf (n, %) | 24,561 (39.0) | 2415 (41.0) | 0.87 (0.82–0.92) | <0.001 | 12,822 (37.8) | 1097 (39.5) | 0.82 (0.75–0.89) | <0.001 | 11,739 (40.3) | 1318 (42.4) | 0.91 (0.84–0.99) | 0.033 |
| Chronic diseasesg (mean, sd) | 2.7 (2.8) | 5.2 (3.8) | 1.04 (1.03–1.05) | <0.001 | 3.1 (3.0) | 5.8 (3.9) | 1.03 (1.02–1.04) | <0.001 | 2.2 (2.4) | 4.6 (3.5) | 1.05 (1.04–1.07) | <0.001 |
| Follow-up outcome | ||||||||||||
| Hospital adm.h (n, %) | - | 5214 (88.6%) | - | - | - | 2441 (87.9%) | - | - | - | 2773 (89.3%) | - | - |
| ICUi adm. (n, %) | - | 325 (5.52%) | - | - | - | 107 (3.85%) | - | - | - | 218 (7.02%) | - | - |
| Deathj (n, %) | - | 1598 (27.2%) | - | - | - | 791 (28.5%) | - | - | - | 807 (26.0%) | - | - |
aDefined as individuals without hospital admission or mortality during the follow-up period;
bDefined as individuals admitted to hospital or dead during the follow-up period;
cOdds ratio of moderate-to-severe infection adjusted by categorical age;
d95% confidence interval;
estandard deviation;
fVersus urban area, according to patients’ administrative health area;
gFrom a list of 153 chronic conditions;
hAdmission to hospital during 15 days before/after the index date;
iAdmission to the Intensive Care Unit;
j30-day all-cause mortality.