Table 3.

Individual slopes and HADS scores at key assessment points

HADS anxiety				HADS depression
Red flag	Last visit [n visits]	β (*4 weeks)	t	Red flag	Last visit	β (*4 weeks)	t
Accepters				Accepters
19	10 [8]	− 2.04	− 1.09	16	8	− 1.12	− 0.65
15	12 [7]	− 1.43	− 5.67	6	8	0.78	2.80
13	7 [8]	− 0.78	− 2.15	10	9	− 0.64	− 2.56
9	7 [3]	− 1.20	− 2.26	12	11	− 0.59	− 0.21
13	3 [9]	− 2.04	− 4.87	4	3	− 0.42	− 1.67
15	7 [6]	− 4.90	− 3.24	12	7	− 4.54	− 4.91
12	9 [4]	− 1.20	− 1.43	6	6	0.06	0.17
12	11 [8]	− 0.48	− 0.63	11	6	− 0.81	− 0.85
14	11 [4]	− 1.32	− 2.14	13	9	− 2.44	− 3.00
13	8 [7]	− 1.37	− 3.27	14	11	− 0.73	− 1.30
13	7 [7]	− 2.16	− 1.38	3	1	− 0.42	− 2.50
19	6 [4]	− 7.22	− 1.71	11	6	− 3.42	− 11.09
		Mean (SD)  − 2.18 (1.94)				Mean (SD)  − 1.19 (1.52)
Refusers				Refusers
7	7 [3]	0.00	0.00	12	12	0.00	0.00
13	9 [6]	− 2.30	− 2.73	11	9	− 1.43	− 4.64
12	9 [8]	− 2.04	− 3.32	9	7	− 1.85	− 3.30
13	13 a [1]			10	10 a
14	10 [4]	3.67	1.01	7	6	− 0.73	− 0.67
13	2 [4]	− 13.27	− 5.64	9	1	− 8.57	− 1.75
11	9 [8]	− 1.20	− 2.69	12	3	− 4.84	− 5.97
3	3 [2]	0.00		16	10	− 24.00
10	6 [7]	− 1.90	− 1.36	12	8	− 2.74	− 1.24
11	6 [3]	− 5.07	− 18.10	7	8	0.45	0.24
12	9 [3]	− 4.79	− 3.35	8	9	1.90	0.72
13	10 [5]	− 2.88	− 2.06	8	8	0.06
9	6 [4]	− 3.36	− 0.17	13	8	− 4.82	− 1.13
		Mean (SD)  − 2.76 (4.05)				Mean (SD)  − 3.88 (6.96)

β estimated linear trend over 4 weeks; β/standard error = t (critical value 1.95).

^aNo further visits after red flag: value carried forward.

Gray-shading denotes improvers defined by β <  − 2.0 indicating clinical relevant reduction in HADS values from red flag to last visit.