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. 2021 Sep 13;49(5):1985–1995. doi: 10.1042/BST20200890

Figure 1. Innate-like and adaptive human γδ T cell sub-compartments.

Figure 1.

Vγ9/Vδ2+ T cells are formed of an innate-like T cell population that possess a semi-invariant T cell receptor (TCR) and reactivity to the microbial-derived metabolite HMB-PP. Whereas post-natal Vδ1+ T cells can be separated into naïve-like and effector populations. Naïve-like Vδ1+ T cells display a diverse TCR repertoire and express CD27, CD28, CD62L, CCR7 and IL7Rα on their cell surface. In contrast, effector Vδ1+ T cells often possess clonally focussed TCRs, express low levels of CD27, up-regulate expression of the endothelial homing receptor CX3C chemokine receptor 1 (CX3CR1) and cytotoxic granzymes and perforin.