Table 1. Identified γδ TCR ligands and gene restrictions.

Human γδ lineage	Tissue	Ligand	Structural fold	Ref.
Vδ restriction
Vδ1	Peripheral blood	CD1b	MHC class I–like	[35]
Vδ1	Peripheral blood	CD1c	MHC class I–like	[36]
Vδ1	Peripheral blood	CD1d	MHC class I–like	[37,38]
Vδ1/Vδ3	Peripheral blood	MR1	MHC class I–like	[39]
Vδ1	Peripheral blood	R-Phycoerythrin	Phycobiliprotein	[40]
Vδ3	-	Annexin A2	Annexin	[43]
Vγ restriction (or pairings)
Vγ4	Enteric	BTNL3-BTNL8	B7-like	[71,73,78]
Vγ9–Vδ2	Peripheral blood	BTN3A-BTN2A	B7-like	[47,63]
Vγ3–Vδ2	Intramuscular	Aminoacyl tRNA synthetase	Class II synthetase	[79]
Vγ4–Vδ5	Peripheral blood	Endothelial protein-C receptor	MHC α1-α2–like	[42]
Vγ9–Vδ1	Peripheral blood	Ephrin type A receptor 2	Ephrin receptor tyrosine kinase	[41]