Figure 1. Increased proliferation among CD8 T cells of septic patients.

(A) Representative gating for CD8 T cell subsets and Ki67 expression from healthy controls and septic patients (within 24 hr of hospital admission). (B) Frequency and (C) number of CD8 T cells among lymphocytes in healthy controls and septic patients. Dashed lines indicate the normal range for the number of CD8 T cells per mL of blood. (D) Frequency of Ki67 expressing CD8 T cells in healthy controls and septic patients. (E) Frequency Ki67 expressing cells among Naïve, Effector (T_Eff), Effector Memory (T_EM), Central Memory (T_CM), and Stem Cell Memory (T_SCM) CD8 T cells from healthy controls and septic patients. Data are representative of 2 independent experiments with 16–27 patients per group. *=p < 0.05. Error bars in represent standard error of the mean.

Figure 1—figure supplement 1. Composition of total and proliferating CD8 T cells in healthy controls and septic hosts.

(A) Frequency of Naïve, Effector (T_Eff), Effector Memory (T_EM), Central Memory (T_CM), and Stem Cell Memory (T_SCM) among CD8 T cells. (B) Frequency of Ki67-expressing cells among Naïve, Effector (T_Eff), Effector Memory (T_EM), Central Memory (T_CM), and Stem Cell Memory (T_SCM) CD8 T cells. Data are representative of two independent experiments with 16–27 patients per group. Error bars in represent standard error of the mean.