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. 2021 Nov 9;15(6):061503. doi: 10.1063/5.0062697

FIG. 3.

FIG. 3.

Classic “microfluidic tumor chip” designs. (a) Microwell-based multiple tumor spheroids culture chip (MTC-chip) cultured tumor under various flow conditions.42 Reprinted with permission from Zhuang et al., Adv. Sci. 6, 1901462 (2019). Copyright 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. (b) A U-shaped array based 3D breast-cancer-on-a-chip for the evaluation of nanoparticle-based drug delivery systems.43 Reprinted with permission from Chen et al., Anal. Chim. Acta 1036, 97 (2018). Copyright 2018 Elsevier B.V. (c) Pneumatically actuated U-shaped arrays for one-step cell localization, spheroids self-assembly, and real-time analysis.44 Reprinted with permission from Liu et al., Lab Chip 15, 1195 (2015). Copyright 2015 The Royal Society of Chemistry. (d) Liquid dome-assisted formation of gradient-sized spheroids on an agarose chip.29 Reprinted from Fang et al., Lab Chip 19, 4093 (2019). Copyright 2019 The Royal Society of Chemistry.