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. 2021 Nov 9;15(6):061503. doi: 10.1063/5.0062697

FIG. 4.

FIG. 4.

Microdroplet technique for high-throughput tumor spheroid generation. (a) A droplet-based microfluidic system that generates cancer cells containing microdroplets at high yield (1000 droplets/min).69 Reprinted with permission from Kwak et al., J. Controlled Release 275, 201 (2018). Copyright 2018 Elsevier B.V. (b) Size-tunable brain tumor spheroids generated by microfluidic droplets are applied for photothermal therapy (PTT) testing.70 Reprinted with permission from Lee et al., Microsyst. Nanoeng. 6, 52 (2020). Copyright 2020 Springer Nature. (c) A droplet-based microfluidic device for constructing tumor spheroids from single cancer cells.71 Reprinted with permission from Wang et al., Adv. Sci. 7, 2000259 (2020). Copyright 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. (d) An integrated droplet-based microfluidic platform for dynamic analysis of cellular interaction, proliferation, and therapeutic efficacy via spatiotemporal profiling on chip.72 Reprinted with permission from Sabhachandani et al., J. Controlled Release 295, 21 (2019). Copyright 2018 Elsevier B.V.