Table 1.

The main components of the MAM.

Number	Classification	Components	References
1	Calcium channels in the outer membrane of the ER and mitochondria, voltage-dependent anion channels	TRPM8, VDAC, IP3R1, GRP75	[30, 31]
2	Enzymes for the synthesis and transfer of lipids	PSS1, PSS2, PEMT, caveolin-1, FACL4, ACAT1, DGAT2	[22, 32–37]
3	Chaperones	Sig1R, CNX, CRT	[38–40]
4	Redox reactive enzymes involved in the ER	ERO 1α	[41]
5	Mitochondrial rho GTPases 1 and mitofusin 2	MiRo 1, Mfn, FUNDC1, Drp	[42–46]

Note: ACAT, acetyl-CoA acetyltransferase 1; ATG14L, autophagy-related 14-like; CNX, Calnexin; CRT, calreticulin; DGAT2, diacylglycerol-O-acyltransferase 2; FACL4, fatty acid CoA ligase 4; Drp1, dynamin-related protein 1; ER, endoplasmic reticulum; ERO 1α, ER oxidoreductin-1α; PEMT, phosphatidyl ethanolamine methyltransferase; GRP75, chaperone 75 kDa glucose- regulated protein; IP3R, inositol-1,4,5-triphosphate receptor; IRE1, inositol-requiring enzyme 1; Mfn, mitofusin 2; TRPM8, transient receptor potential melastatine 8; PERK, protein kinase-like ER kinase; PS, phosphatidylserine; PSS, PS synthase; Sig1R, Sigma 1 receptor; VDAC1, voltage-dependent anion-selective channel protein 1.