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. 2021 Oct 26;8:759292. doi: 10.3389/fmed.2021.759292

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Copyright © 2021 Jin, Yan, Lu, Lu, Zhang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study of the phenotype and function of natural killer (NK) cells in chronic hepatitis B (CHB) patients. (A) Typical results showing, the expression of the NK receptor, and the secretion of cytokine by NK cells, as well as the Mean fluorescence intensity (MFI) of the granzyme (blue) and perforin (red) in NK cells. (B) Comparison of NK cell numbers and phenotypes in CHB patients (n = 48) and healthy controls (n = 15), including the numbers of two subpopulations with high and low CD56 expression, and the expression of NK inhibitory receptor NKG2A and activating receptor NKp30. (C) Comparison of NK cell granzyme, perforin (n = 48), and IFN-γ secretion functions in CHB (n = 31) and healthy control groups (n = 15).