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. 2021 Feb 1;26(9):4884–4895. doi: 10.1038/s41380-021-01026-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Ordered logit model of level of education for CNV types and PRS extremes in individuals with no SNPD (n = 25,944). Nine hundred and ten individuals were removed due to incomplete information on education, education reported as “ongoing”, or education reported as “other”. B Years of education lost due to CNV types and PRS extremes in FINRISK individuals with no SNPD (n = 21,961). Two hundred and forty-nine participants were removed from this analysis due to incomplete information on education. C Ordered logit model of household income (1–9) for CNV types and matched PRS extremes in individuals with no SNPD (n = 25,693). In total, 1161 participants were removed from analysis due to incomplete data on income. D When adjusting for education, most economic impacts from PRS and high-risk CNVs are accounted for. E Subjective health of CNV types and PRS extremes in individuals with no diagnosis of SNPD (n = 26,603). Subjective health was analyzed in an ordered logit model, where covariates were age, sex, and PCs 1–10. Two hundred and fifty-one participants were removed from the analysis due to incomplete data on subjective health. A circle denotes the use of a fixed-effect model; a triangle denotes a random effects model. Estimated effect is plotted with 95% confidence intervals, with point estimate denoted under the effect, and Bonferroni-corrected p-value denoted above.