Table 1.
Sample description.
| Characteristic | CNV carrier (N) |
Non-carrier (N) | Total (N) | CNV carrier (%) | ||
|---|---|---|---|---|---|---|
| Clinical group | ||||||
| Controls | 16 | 1997 | 2013 | 0.8% | ||
| Relatives | 2 | 644 | 646 | 0.3% | ||
| Patients | 11 | 758 | 769 | 1.5% | ||
| Centre | ||||||
| Munich | 3 | 949 | 952 | 0.3% | ||
| Perth | 6 | 548 | 554 | 1.1% | ||
| London | 2 | 478 | 480 | 0.5% | ||
| Maastricht | 4 | 395 | 399 | 1.0% | ||
| Amsterdam | 4 | 329 | 333 | 1.2% | ||
| Utrecht | 5 | 304 | 309 | 1.6% | ||
| Groningen | 5 | 310 | 315 | 1.6% | ||
| Pamplona | 0 | 44 | 44 | 0.0% | ||
| Edinburgh | 0 | 42 | 42 | 0.0% | ||
| Sex | ||||||
| Males | 16 | 1743 | 1759 | 0.9% | ||
| Females | 13 | 1656 | 1669 | 0.8% | ||
| Characteristic | CNV carrier (N) | CNV carrier (mean/SD) | Non-carrier (N) | Non-carrier (mean/SD) | Total (N) | Total (mean/SD) |
| Age | 29 | 39.9 (15.6) | 3399 | 43.7 (15.9) | 3428 | 43.7 (15.9) |
| Cognitive performance | ||||||
| Block design | 21 | 50.6 (24.9) | 2726 | 57.4 (23.6) | 2747 | 57.4 (42.0) |
| Digit span | 5 | 60.5 (4.5) | 1265 | 50.7 (15.1) | 1270 | 50.7 (9.4) |
| RAVLT immediate Recall | 24 | 46.5 (16.6) | 1882 | 54.7 (14.5) | 1906 | 54.6 (14.9) |
| RAVLT delayed recall | 24 | 14.6 (7.8) | 1865 | 17.7 (6.9) | 1889 | 17.7 (6.6) |
Demographic information for participants with data on schizophrenia-associated CNVs. Two participants with schizophrenia-associated CNV were identified in the samples failing QC for CNV burden, these were included only in the analysis of schizophrenia-associated CNVs; thus giving a sample of 3428 participants for the analysis of schizophrenia-associated CNVs and 3426 for the analysis of CNV burden. CNV carriers refer to individuals who were identified as carrying a known schizophrenia-associated CNV (see Supplementary Table 3).
RAVLT Rey Auditory Verbal Learning Test, SD standard deviation.