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. 2020 May 18;26(9):5124–5139. doi: 10.1038/s41380-020-0754-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The plots show the correlation between chronological age and predicted brain age in the tenfold cross-validation of the ridge regression in the control train sample, the out-of-sample validation of the test samples (controls and MDD patients) from the ENIGMA MDD working group, and generalizability to completely independent test samples (controls only) from the ENIGMA BD working group (top to bottom). The colors indicate scanning sites and each circle represents an individual subject. Diagonal dashed line reflects the line of identity (x = y).