Table 1.
Patient baseline characteristics
| Parameter | All patients |
Prior cinacalcet use |
P value | |
|---|---|---|---|---|
| Nonusers |
Users |
|||
| N = 253 | n = 98 | n = 155 | ||
| Sex | ||||
| Male | 177 (70.0) | 69 (70.4) | 108 (69.7) | 0.902 |
| Age, yr | 60.9 ± 11.4 | 63.8 ± 11.3 | 59.2 ± 11.1 | 0.002 |
| Body mass index, kg/m2 | 24.6 ± 4.6 | 25.0 ± 4.5 | 24.3 ± 4.6 | 0.202 |
| Primary disease | ||||
| Diabetic nephropathy | 66 (26.1) | 27 (27.6) | 39 (25.2) | 0.560 |
| Chronic glomerulonephritis | 104 (41.1) | 35 (35.7) | 69 (44.5) | |
| Nephrosclerosis | 31 (12.3) | 13 (13.3) | 18 (11.6) | |
| Other | 52 (20.6) | 23 (23.5) | 29 (18.7) | |
| Duration of dialysis, mo | 126.5 ± 86.2 | 92.6 ± 70.9 | 147.9 ± 88.3 | < 0.001 |
| Type of dialysis | ||||
| HD | 200 (79.1) | 81 (82.7) | 119 (76.8) | 0.263 |
| HDF | 53 (20.9) | 17 (17.3) | 36 (23.2) | |
| Dry weight, kg | 62.2 ± 13.9 | 63.3 ± 14.2 | 61.6 ± 13.7 | 0.342 |
| Dialysis efficiency, spKt/V | 1.50 ± 0.29 | 1.46 ± 0.28 | 1.52 ± 0.29 | 0.092 |
| Use of vitamin D receptor activator | ||||
| Users | 217 (85.8) | 80 (81.6) | 137 (88.4) | 0.134 |
| Oral only | 81 (32.0) | 38 (38.8) | 43 (27.7) | 0.018 |
| Parenteral | 136 (53.8) | 42 (42.9) | 94 (60.6) | |
| Intact PTH, pg/ml | 374 (298, 472) | 336 (278, 415) | 390 (311, 511) | 0.002 |
| Corrected calcium, mg/dl | 9.5 ± 0.6 | 9.3 ± 0.5 | 9.6 ± 0.6 | < 0.001 |
| Phosphate, mg/dl | 5.8 ± 1.3 | 5.7 ± 1.4 | 5.8 ± 1.3 | 0.448 |
| Corrected calcium−phosphate product, mg2/dl2 | 54.6 ± 12.3 | 52.9 ± 12.6 | 55.7 ± 12.1 | 0.073 |
| Bone-specific alkaline phosphatase, μg/l | 17.6 ± 9.9 | 17.0 ± 8.6 | 17.9 ± 10.7 | 0.744 |
| Tartrate-resistant acid phosphatase 5b, mU/dl | 783.2 ± 394.5 | 682.3 ± 348.7 | 846.9 ± 409.3 | < 0.001 |
| Procollagen type 1 N-terminal-propeptide, μg/l | 437.3 ± 287.5 | 363.4 ± 233.1 | 484.0 ± 308.8 | 0.002 |
| Fibroblast growth factor 23, pg/ml | 13 600 (6130, 28 600) | 12 150 (5010, 24 200) | 15 300 (6640, 30 700) | 0.120 |
| Largest parathyroid gland volume, mm3 | 332.1 ± 627.1 | 290.6 ± 613.1 | 354.7 ± 636.4 | 0.025 |
Data are number (%), mean ± SD, or median (interquartile range). ꭓ2 Test (categorical), unpaired t test or Mann–Whitney U test (continuous). HD, hemodialysis; HDF, hemodiafiltration; PTH, parathyroid hormone.