Table 5.
Impact of adherence to antithrombotic therapy on risk of stroke and bleeding in patients with chronic liver disease (CLD) compared with those without CLD as a reference. Analyses for risk of stroke were performed based on patients stratified according to the time they spent not taking medications. Analyses for risk of bleeding were performed in patients who were adherent. Adjusted hazard ratios (HRs) are reported.
| Anticoagulant therapy | |||||
|---|---|---|---|---|---|
| HR | Lower CI | Upper CI | P value | Outcome | |
| Not taking medication for < 1 week | |||||
| With CLD | 1.435 | 0.943 | 2.182 | 0.092 | Stroke |
| Not taking medication for 1 week to 1 month | |||||
| With CLD | 0.802 | 0.258 | 2.498 | 0.70 | Stroke |
| Not taking medication for 1 month to 3 months | |||||
| With CLD | 1.129 | 0.281 | 4.534 | 0.86 | Stroke |
| Not taking medication for 3 months to 6 months | |||||
| With CLD | 1.097 | 0.649 | 1.854 | 0.73 | Stroke |
| Not taking medication for > 6 months | |||||
| With CLD | 1.143 | 0.852 | 1.533 | 0.37 | Stroke |
| Patients who were adherent (PDC > 80%) | |||||
| With CLD | 1.338 | 0.959 | 1.866 | 0.086 | Bleeding |
| Antiplatelet therapy | |||||
| HR | Lower CI | Upper CI | P value | Outcome | |
| Not taking medication for < 1 week | |||||
| With CLD | 1.454 | 1.187 | 1.781 | 0.00030 | Stroke |
| Not taking medication for 1 week to 1 month | |||||
| With CLD | 1.587 | 0.954 | 2.638 | 0.075 | Stroke |
| Not taking medication for 1 month to 3 months | |||||
| With CLD | 1.058 | 0.549 | 2.038 | 0.87 | Stroke |
| Not taking medication for 3 months to 6 months | |||||
| With CLD | 1.422 | 1.141 | 1.772 | 0.0017 | Stroke |
| Not taking medication for > 6 months | |||||
| With CLD | 1.303 | 1.116 | 1.521 | 0.00082 | Stroke |
| Patients who were adherent (PDC > 80%) | |||||
| With CLD | 2.021 | 1.729 | 2.363 | < 0.0001 | Bleeding |