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. 2021 Sep 8;6(11):2862–2884. doi: 10.1016/j.ekir.2021.08.033

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© 2021 International Society of Nephrology. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Flow chart showing the design of the study for the suspected primary hyperoxaluria (PH) and Dent disease (DD) popuations. (a) The composition of the Sanger-resolved populations and number of PH-negative (PHN) and DD-negative (DDN) patients screened with the targeted next generation sequencing (tNGS) panel are shown. (b) Mutated genes detected from the tNGS of the PHN (left) and DDN (right) populations. (c) An overall summary of the associated genes in the resolved biallelic (left) and monoallelic (right) families.