Table 3.
Diagnostic value of WB-MRI versus the [18F]FDG-PET/CT-based reference standard for the early response assessment and restaging of paediatric Hodgkin’s lymphoma
| Observed agreement (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | |
|---|---|---|---|---|---|
| Early response assessment | |||||
| MRI - DWI | 29% (15/51, 19–43%) | 92% (64–100%) | 8% (2–21%) | 26% (14–40%) | 75% (19–99%) |
| MRI + DWI | 65% (33/51, 51–76%) | 54% (25–81%) | 68% (51–82%) | 37% (16–62%) | 81% (64–93%) |
| Intrinsic MRI* | 71% (36/51, 57–81%) | 77% (46–95%) | 68% (51–82%) | 45% (24–68%) | 90% (73–98%) |
| Restaging | |||||
| MRI - DWI | 38% (5/13, 18–64%) | NA | 45% (17–77%) | NA | 83% (36–100%) |
| MRI + DWI | 69% (9/13, 42–87%) | NA | 82% (48–98%) | NA | 90% (55–100%) |
| Intrinsic MRI* | 69% (9/13, 42–87%) | NA | 82% (48–98%) | NA | 90% (55–100%) |
CI, confidence interval; DWI, diffusion-weighted imaging; MRI, magnetic resonance imaging; NA, not applicable, insufficient numbers to perform analysis; PPV, positive predictive value; NPV, negative predictive value. *Intrinsic MRI, WB-MRI DWI after removal of reader error