Table 3.
Comparison of patients with LD to cognitively normal patients with HSCR
| Under 18 | LD (n = 15) | Cognitively normal (n = 47) | P |
| Age, y (median [IQR]) | 9 [7–14] | 11 [7–14] | 0.57 |
| Sex, m:f | 10:5 (2:1) | 37:10 (3.7:1) | 0.34 |
| Down syndrome, n (%)* | 7 (47) | - | - |
| Rectosigmoid segment, n (%) | 10 (66) | 37 (79) | 0.30 |
| Duhamel pull-through, n (%) | 15 (100) | 46 (98) | 0.72 |
| Adults | LD (n = 17) | Cognitively normal (n = 139) | P |
| Age, y (median [IQR]) | 27 [23.5–31.5] | 29 [25–34] | 0.42 |
| Sex, m:f | 11:6 (1.8:1) | 98:41 (2.4:1) | 0.62 |
| Down syndrome, n (%)* | 11 (65) | - | - |
| Rectosigmoid segment, n (%) | 10 (59) | 104 (75) | 0.26 |
| Duhamel pull-through, n (%) | 16 (94) | 108 (78) | 0.20 |
*Other conditions included Mowat-Wilson syndrome and Goldberg-Schpritzen syndrome, along with various chromosomal anomalies and global developmental delay with or without autism