Table 4.
Baseline characteristics — case patients
| Nr | Sex | Age | Tumour type | Treatment preceding ASL | Best response (mo) | Time ASL-MP (d) | Time surgery 1-MP (mo) | Time MRI-surgery 2 (d) | Seizures | ASL |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | W | 43 | ODG 1p/19q-codel, IDH mt | No | N/A | 17 | 42 | No 2nd surgery | Yes | 2 |
| 2 | M | 48 | DA IDH mt | No | N/A | 18 | 12 | No contrast-enhancement on follow-up MRI | No | 1 |
| 3 | M | 26 | DA IDH mt | TMZ 9 cycles | SD (24) | 112 | 33 | No 2nd surgery | No | 1 |
| 4 | W | 55 | DA IDH wt | RT 50.4 Gy, TMZ 12 cycles | SD (7) | 203 | 17 | No 2nd surgery | Yes | 0 |
| 5 | W | 45 | DA IDH mt | RT 50.4 Gy | SD (36) | 100 | 44 | No 2nd surgery | No | 0 |
| 6 | M | 57 | DA IDH mt | RT 50.4 Gy, TMZ 12 cycles | PR (4) | 31 | 23 | No 2nd surgery | No | 2 |
| 7 | W | 49 | DA IDH mt | RT 50.4 Gy, TMZ 9 cycles | MR (11) | 85 | 116 | 1 | Yes | 1 |
| 8 | M | 47 | DG-NOS | RT 50.4 Gy | SD (20) | 86 | 37 | No 2nd surgery | No | 0 |
| 9 | M | 50 | DA IDH wt | RT 50.4 Gy, TMZ 14 cycles | PR (17) | 135 | 37 | 18 | No | 1 |
| 10 | W | 25 | DA IDH mt | RT 50.4 Gy, TMZ 6 cycles | SD (47) | 188 | 111 | 258 | Yes | 1 |
| 11 | M | 49 | DG-NOS | TMZ 3 cycles | TP | 116 | 3 | No 2nd surgery | No | 1 |
Nr, number of case patient; W, woman; M, man; ODG 1p/19q-codel, 1p/19q-codeleted oligodendroglioma; DA, diffuse astrocytoma; IDH, Isocitrate dehydrogenase; mt, mutated; wt, wildtype; DG-NOS, diffuse glioma not otherwise specified; RT, radiotherapy; TMZ, temozolomide; Gy, Gray; Best response: best response to treatment using RANO criteria in months [8]; SD, stable disease; PR, partial response; MR, minor response; TP, tumour progression; N/A, not applicable; Time ASL-MP (d), time from index ASL-MRI to malignant progression in days; ASL, arterial spin labeling MRI; Time surgery 1- MP (mo), time from first surgery to malignant progression in months; Time MRI – surgery 2 (d), time from MRI showing MP to second surgery in days (recurrence-resection), Seizures, seizures before ASL; ASL, score ASL of first radiologist.