Table 2.
Baseline features per week 16 fluid statusa
| Without fluid at week 16 (n = 143b) |
With fluid at week 16 (n = 102b) |
|
|---|---|---|
| Age, years | 74.3 (8.2) | 73.6 (7.9) |
| Male, n (%) | 102 (71.3) | 75 (73.5) |
| BCVA, ETDRS letters | 55.5 (12.4) | 54.5 (12.8) |
| CRT, µm | 370.8 (137.9) | 390.0 (145.1) |
| Type of AMD,c n (%) | ||
| Typical AMD | 80 (55.9) | 70 (68.6) |
| PCV | 59 (41.3)d | 30 (29.4)d |
| RAP | 9 (6.3)d | 4 (3.9)d |
| Type of CNV lesions on FA,e n (%) | ||
| Classic | 51 (35.7) | 26 (25.5) |
| Classic and occult | 20 (14.0) | 11 (10.8) |
| Occult | 70 (49.0) | 63 (61.8) |
| No CNV | 1 (0.7) | 0 (0.0) |
| IRF, n (%) | 54 (37.8)f | 33 (32.4) |
| SRF, n (%) | 116 (81.1)g | 91 (89.2) |
| PED, n (%) | 80 (55.9)g | 80 (78.4) |
| Mean height of PED, µm | 271.1 (179.2) | 341.4 (266.8) |
| Mean width of PED, µm | 2293.1 (1231.5) | 2370.1 (1553.9) |
| Subretinal hemorrhage, n (%) | 72 (50.3)d | 33 (32.4)g |
| Intraretinal hemorrhage, n (%) | 39 (27.3)d | 19 (18.6)g |
Full analysis set (N = 246). All values are mean (SD) unless otherwise stated
aFluid status was assessed by the investigator based on the presence of any new or persistent fluid (on OCT)
bTwo adjustment groups are combined (IVT-AFL-2 W and IVT-AFL-4 W); fluid status was unknown in the IVT-AFL-2 W group (n = 1)
cSome patients were diagnosed as 1 or 2 subtypes
dMissing (n = 1)
eUnknown for patients without fluid (n = 1) and with fluid (n = 2)
fMissing (n = 2), unknown (n = 3)
gMissing (n = 2)
AMD, age-related macular degeneration; BCVA, best-corrected visual acuity; CNV, choroidal neovascularization; CRT, central retinal thickness; ETDRS, Early Treatment Diabetic Retinopathy Study; FA, fluorescein angiography; IRF, intraretinal fluid; PCV, polypoidal choroidal vasculopathy; PED, pigment epithelial detachment; RAP, retinal angiomatous proliferation; SRF, subretinal fluid