Table 3.

Dimensions and qualitative measures of primary tumour and lymph node on 0-, 6- and 12-week MRI studies with interval changes for all patients

Primary tumour
	Pre (n = 39)	6 (n = 39)	12 (n = 39)	0–6 absolute and % change (n = 39)	p value	6–12 absolute and % change (n = 39)	p value
Linear long axis (mm)	27 [21.5, 31.5]	8 [0, 13]	8 [0, 13]	19 [14, 25.5] − 73.3% [− 100, − 54.6%]	p < .001	0 [0, 0] 0 [0, 0]	p = .98
Volume (mm2)	10,506 [5304, 13,446]	562 [64, 1068]	480 [0, 908]	9908 [3672, 12,426] − 95.5% [− 89.6, − 99.4%]	p < .001	36 [16,82] − 6.9% [− 2.6, − 14.6%]	p < .001
T2w morphology score 0	0	19	19
T2w morphology score 1	0	11	11
T2w morphology score 2	0	9	9
T2w morphology score 3	39	0	0
T2w morphology mean score	3	0.7	0.7		p < .001		p = 1
DWI score 0	0	19	19
DWI score 1	2	20	20
DWI score 2	8	0	0
DWI score 3	9	0	0
DWI score 4	20	0	0
DWI mean score	3.2	0.5	0.5		p < .001		p = 1
Lymph node
	Pre (n = 42)	6 (n = 42)	12 (n = 42)	0–6 absolute and % change (n = 42)	p value	6–12 absolute and % change (n = 42)	p value
Linear long axis (mm)	26 [19.5, 32.8]	12 [10, 16]	10 [9, 13]	12 [6.3, 18.8]− 50.8% [− 59.6, − 34.3%]	p < .001	2 [0, 3] − 12.9% [− 23.2, 0%]	p < 0.05
Linear short axis (mm)	18.5 [14, 22.8]	8.5 [6, 10.8]	7 [6, 9]	9.5 [7,14]− 56.6% [− 64.8, − 42.5%]	p < .001	1.5 [0, 2] − 16.7% [− 24.3, 0%]	p < 0.05
Volume (mm2)	4902 [2717, 10,161]	852 [463, 1232]	496 [246, 849]	3363 [1818, 9243] − 81.5% [− 68.8, − 92.0%]	p < .001	235 [108, 443] − 31.5% [− 13.5, − 46.4%]	p < .001
Necrosis score 0	6	22	30
Necrosis score 1	26	18	9
Necrosis score 2	10	2	3
Necrosis mean score	1.1	0.5	0.4		p < .001		p < 0.05

p < 0.05 or p < 0.001 are statistically significant (marked in bold)

Summary statistics: median [inter-quartile range]; mean ± standard deviation