Table 4.
Dimensions and qualitative measures of primary tumour and lymph node on 0-, 6- and 12-week MRI studies with interval changes for HPV-OPC and other HNSCC participants
| Primary site HPV-OPC | |||||||
| Pre (n = 29) | 6 (n = 29) | 12 (n = 29) | 0–6 absolute and % change (n = 29) | p value | 6–12 absolute and % change (n = 29) | p value | |
| Long axis (mm) | 27 [21, 34] | 0 [0, 14] | 0 [0, 14] | 18 [14, 27] − 100% [− 100, − 47.4%] | p < .001 | 0 [0, 0] 0 [0, 0] | p = .98 |
| Volume (mm2) | 10,834 [6312, 17,199] | 392 [75, 922] | 360 [40, 887] | 10,291 [5985, 14,251] − 96.5% [− 92.5, − 99%] | p < .001 | 36 [20.5, 66.5] − 7.5% [− 3.2, − 17.7%] | p < .001 |
| T2w morphology score 0 | 0 | 15 | 15 | ||||
| T2w morphology score 1 | 0 | 9 | 9 | ||||
| T2w morphology score 2 | 0 | 5 | 5 | ||||
| T2w morphology score 3 | 29 | 0 | 0 | ||||
| T2w morphology mean score | 2 | 0.7 | 0.7 | p < .001 | p = 1 | ||
| DWI score 0 | 0 | 15 | 15 | ||||
| DWI score 1 | 1 | 14 | 14 | ||||
| DWI score 2 | 5 | 0 | 0 | ||||
| DWI score 3 | 6 | 0 | 0 | ||||
| DWI score 4 | 17 | 0 | 0 | ||||
| DWI mean score | 3.3 | 0.5 | 0.5 | p < .001 | p = 1 | ||
| Nodal site HPV-OPC | |||||||
| Pre (n = 32) | 6 (n = 32) | 12 (n = 32) | 0–6 absolute and % change (n = 32) | p value | 6–12 absolute and % change (n = 32) | p value | |
| Long axis (mm) | 27.5 [22.8, 33.3] | 13 [10, 16.3] | 9.5 [9, 13] | 13.5 [8.8, 21] − 52.0% [− 60.2, 45.0%] | p < .001 | 1.5 [0.8, 3.3] − 11.8% [− 22.6, − 4.7%] | p < .001 |
| Short axis (mm) | 20.1 ± 7.2 | 8.4 ± 2.8 | 7.0 ± 2.2 | 11.6 ± 6.0 − 55.7% ± 14.1% | p < .001 | 1.5 ± 1.6 − 15.5% ± 17.0% | p < .001 |
| Volume (mm2) | 4902 [2820, 10,193] | 894 [601, 1248] | 540 [291, 838] | 3363 [2187, 9303] − 81.5% [− 70.2, − 92.0%] | p < .001 | 275 [128, 465] − 32.9 [− 16.3, − 41.8%] | p < .001 |
| Necrosis score 0 | 4 | 16 | 22 | ||||
| Necrosis score 1 | 21 | 15 | 8 | ||||
| Necrosis score 2 | 7 | 1 | 2 | ||||
| Necrosis mean score | 1.1 | 0.5 | 0.4 | p < .001 | p < .001 | ||
| Primary site other HNSCC | |||||||
| Pre (n = 10) | 6 (n = 10) | 12 (n = 10) | 0–6 absolute and % change (n = 10) | p value | 6–12 absolute and % change (n = 10) | p value | |
| Long axis (mm) | 25 [22.8, 27.8] | 8.5 [0, 9] | 8.5 [0, 9] | 21.5 [18.3, 24.3] − 70.60% [− 100, − 62.5%] | p < .001 | 0 [0, 0] 0 [0, 0] | p = .97 |
| Volume (mm2) | 8560 [3340, 12,360] | 762 [0,1320] | 654 [0, 1288] | 8560 [2108, 11,164] − 93.3% [− 80.2, − 100%] | p < .05 | 36 [0,108] − 3.1% [0, − 14.7%] | p < .05 |
| T2w morphology score 0 | 0 | 4 | 4 | ||||
| T2w morphology score 1 | 0 | 3 | 3 | ||||
| T2w morphology score 2 | 0 | 3 | 3 | ||||
| T2w morphology score 3 | 10 | 0 | 0 | ||||
| T2w morphology mean score | 3 | 0.9 | 0.9 | p < .001 | p = 1 | ||
| DWI score 0 | 0 | 4 | 4 | ||||
| DWI score 1 | 1 | 6 | 6 | ||||
| DWI score 2 | 3 | 0 | 0 | ||||
| DWI score 3 | 4 | 0 | 0 | ||||
| DWI score 4 | 2 | 0 | 0 | ||||
| DWI mean score | 2.7 | 0.6 | 0.6 | p < .001 | p = 1 | ||
| Nodal site other HNSCC | |||||||
| Pre (n = 10) | 6 (n = 10) | 12 (n = 10) | 0–6 absolute and % change (n = 10) | p value | 6–12 absolute and % change (n = 10) | p value | |
| Long axis (mm) | 21.7 ± 8.4 | 12.3 ± 4.6 | 9.9 ± 4.2 | 9.4 ± 8.0 − 38.7% ± 21.3% | p < .001 | 2.4 ± 4.0 − 15.8% ± 32.6% | p = .09 |
| Short axis (mm) | 15.9 ± 4.9 | 7.7 ± 2.2 | 7.1 ± 2.0 | 8.2 ± 5.2 − 47.2% ± 19.8% | p < .001 | 0.6 ± 1.5 − 4.9% ± 21.9% | p = .24 |
| Volume (mm2) | 4649 [2008, 8701] | 545 [254, 991] | 357 [168, 908] | 2683 [1561, 8453] − 83.7% [− 55.4, − 93.2%] | p < .05 | 120 [15.0, 385] − 19.9% [5.7, − 57.2%] | p < .05 |
| Necrosis score 0 | 2 | 6 | 8 | ||||
| Necrosis score 1 | 5 | 3 | 1 | ||||
| Necrosis score 2 | 3 | 1 | 1 | ||||
| Necrosis mean score | 1.1 | 0.5 | 0.3 | p < .001 | p < 0.05 | ||
p < 0.05 or p < 0.001 are statistically significant (marked in bold)
Summary statistics: mean ± standard deviation or median [inter-quartile range]