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. 2021 Nov 12;12:6559. doi: 10.1038/s41467-021-26803-w

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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Fig. 1 — K18-hACE2 mice of both sexes (~1:1 ratio) were infected intranasally with USA-WA1/2020 (WA) of lineage A bearing 614D, New York-PV09158/2020 (NY) of lineage B.1.3 bearing 614G, USA/CA_CDC_5574/2020 (CA) of lineage B.1.1.7 or hCoV-19/South Africa/KRISP-EC-K005321/2020 (SA) of lineage B.1.351 at indicated doses in an ABSL-3 biocontainment. Data are expressed as mean ± s.e.m of 6–8 mice/group (WA (614D) (10³ TCID₅₀/mouse): n = 8 mice/group; WA (614D) (10⁴ TCID₅₀/mouse): n = 7 mice/group; NY (614G) (10² TCID₅₀/mouse): n = 6 mice/group; NY (614G) (10³ TCID₅₀/mouse): n = 8 mice/group; CA (B.1.1.7) (10² TCID₅₀/mouse): n = 6 mice/group; SA (B.1.351) (10² TCID₅₀/mouse): n = 6 mice/group; naïve: n = 4 mice/group). *p < 0.05 and **p < 0.01 by two-way mixed ANOVA (cutaneous temperature change) or by Log-rank (Mantel-Cox) test (survival curves). (a) Body weight (BW); (b) cutaneous temperature change; (c) survival.