The use of a combination corticosteroid and antibiotic is common in ocular inflammatory conditions with a risk of superficial bacterial infection providing patient convenience and potentially improving adherence

A review of the literature indicates loteprednol etabonate 0.5% and tobramycin 0.3% (LE/T) ophthalmic suspension is effective for the treatment of blepharokeratoconjunctivitis in adults with efficacy comparable to that of dexamethasone 0.1%/tobramycin 0.3%, but with a lower propensity to impact intraocular pressure. While the combination appears well tolerated in children with blepharitis or blepharoconjunctivitis, large studies with no confounders are required to demonstrate efficacy compared to vehicle

In vitro, tobramycin demonstrated potent activity against bacterial species implicated in blepharitis

Together, published data demonstrate the utility of LE/T suspension for the treatment of the blepharokeratoconjunctivitis in adults