Table 5:

Effect of study site and surgeon experience variability on (i) in vivo accuracy of PTeye® with surgeon as the gold standard, (ii) ex vivo accuracy of PTeye® with histology as gold standard and (iii) ex vivo accuracy of surgeons with histology as gold standard. The effects of these study design variables were analyzed using generalized linear mixed-effect model with logistic regression for both in vivo and ex vivo analysis.

Effect of study design variables on in vivo accuracy of PTeye®. Gold Standard: Surgeon opinion
Study Design Variable	Odds Ratio	95% Confidence Interval	p-value
Site 2 vs Site 1	2.53	0.91 – 7.00	0.07
Site 3 vs Site 1	2.43	0.97 – 6.06	0.06
Senior vs Junior Surgeons	1.89	0.84 – 4.26	0.13
Effect of study design variables on ex vivo accuracy of PTeye®. Gold Standard: Histology
Study Design Variable	Odds Ratio	95% Confidence Interval	p-value
Site 2 vs Site 1	2.37	0.44 – 12.71	0.31
Site 3 vs Site 1	2.35	0.76 – 7.28	0.14
Senior vs Junior Surgeons	0.44	0.12 – 1.68	0.23
Effect of study design variables on ex vivo accuracy of surgeons. Gold Standard: Histology
Study Design Variable	Odds Ratio	95% Confidence Interval	p-value
Site 2 vs Site 1	0.64	0.12 – 3.38	0.60
Site 3 vs Site 1	0.80	0.24 – 2.64	0.71
Senior vs Junior Surgeons	3.14	1.13 – 8.70	0.03**

^**p-value < 0.05 is suggestive of that particular variable having a significant effect on the accuracy in tissue classification accuracy.