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. 2021 Nov 12;11:22164. doi: 10.1038/s41598-021-01780-8

Figure 5.

Figure 5

Treatment with ΔNS1 influenza virus protects C57BL/6 mice against lethal infection with Sendai virus. All mice were challenged intranasally with a lethal dose of Sendai virus corresponding to (A) 5 × 105 PFU or (B) 1.5 × 105 PFU. The percentage of mice surviving the challenge is represented. (A) Groups of five mice were treated intranasally with 2.5 × 105 PFU of ΔNS1 virus at the indicated times. (B) Groups of five mice were intranasally treated at − 24 h and + 24 h with respect to the infection with Sendai virus with 2.5 × 105 PFU of ΔNS1 or with the indicated amounts of IFN-β.