Table 2.
Rates of change in VSTM function per year. The first row indicates the change over time within each group (change/year). The second row compares the rate of change for each patient group to that of controls (difference in change/year).
| Change per year | Controls (N = 19) | Adjusted mean [95% CI] Group difference [95% CI] (control as reference) |
||
|---|---|---|---|---|
| Early PMCs (N = 12) | Late PMCs (N = 11) | Symptomatic carriers (N = 6) | ||
| Identification performance: % change in odds of correct response | ||||
| Overall | −0.4 [-8.0, 7.8] | 0.8 [-6.8, 8.9] | −5.6 [-13.8, 3.4] | −15.3 [-25.5, -3.7]* |
| NA | 1.2 [-9.2, 12.8] | −5.2 [-16.1, 7.2] | −14.9 [-26.8, -1.1]* | |
| Localisation error: change in % error | ||||
| Overall | 0.4 [-2.1, 3.1] | 0.3 [-2.4, 3.1] | 4.1 [0.9, 7.4]* | 7.0 [0.6, 13.8]* |
| NA | −0.1 [-3.8, 3.7] | 3.6 [-0.4, 7.9] | 6.5 [-0.4, 13.9] | |
| 3-items | 0.4 [-2.2, 3.1] | 1.4 [-1.5, 4.3] | 4.0 [0.7, 7.5]* | 7.3 [0.5, 14.6]* |
| NA | 0.9 [-3.0, 5.0] | 3.6 [-0.7, 8.1] | 6.9 [-0.5, 14.7] | |
| 3-items, 1s | 0.8 [-2.2, 3.9] | 0.0 [-3.3, 3.4] | 1.4 [-2.3, 5.3] | 9.9 [1.7, 18.8]* |
| NA | −0.8 [-5.2, 3.8] | 0.6 [-4.1, 5.6] | 9.0 [0.3, 18.5]* | |
| 3-items, 4s | 0.0 [-3.0, 3.1] | 2.7 [-0.7, 6.2] | 6.9 [2.9, 11.0]** | 4.8 [-3.4, 13.6] |
| NA | 2.7 [-1.9, 7.4] | 6.9 [1.8, 12.2]** | 4.7 [-3.9, 14.2] | |
| 1-item | 0.6 [-3.2, 4.4] | −3.3 [-7.3, 0.8] | 4.4 [-0.5, 9.5] | 5.5 [-4.7, 16.9] |
| NA | −3.9 [-9.1, 1.7] | 3.8 [-2.3, 10.3] | 5.0 [-5.9, 17.0] | |
| 1-item, 1s | 0.9 [-3.1, 5.1] | −4.6 [-8.8, -0.2]* | 1.7 [-3.4, 7.0] | 8.1 [-3.3, 20.8] |
| NA | −5.5 [-11.0, 0.4] | 0.7 [-5.6, 7.5] | 7.1 [-4.9, 20.5] | |
| 1-item, 4s | 0.2 [-3.8, 4.3] | −2.0 [-6.3, 2.4] | 7.2 [1.8, 12.8]** | 3.0 [-7.7, 15.0] |
| NA | −2.2 [-7.9, 3.9] | 7.0 [0.2, 14.2]* | 2.8 [-8.6, 15.7] | |
| Swap error: change in √proportion | ||||
| Overall | −0.001 [-0.014, 0.013] | −0.010 [-0.026, 0.006] | 0.001 [-0.018, 0.019] | −0.016 [-0.043, 0.011] |
| NA | −0.009 [-0.030, 0.012] | 0.001 [-0.022, 0.024] | −0.015 [-0.045, 0.014] | |
| Block 1, 4s | −0.014 [-0.035, 0.005] | −0.011 [-0.036, 0.013] | 0.014 [-0.014, 0.041] | −0.017 [-0.059, 0.026] |
| NA | 0.004 [-0.028, 0.036] | 0.029 [-0.005, 0.063] | −0.002 [-0.049, 0.045] | |
Adjusted mean difference in rate of change per year by group and compared to controls. CI= Confidence intervals; NA = not applicable; PMC = presymptomatic mutation carrier. Bold = significant; *: significant at p < 0.05. **: significant at p < 0.01; % change in odds calculated as (odds ratio-1)*100.