Table 1.

Mean overall reduction in bacterial density (log₁₀ CFU/mL ± standard deviation) using alternative C/T Css regimens for each isolate.

	ST175 (10-023)	ST175 (09-012)	ST175 (07-016)
	Log diff day 10a	Log diff day 10	Log diff day 10
C/T 3 g q24 h CI Css 20 vs Control	− 2.48 ± 0.14	–	–
C/T 6 g q24 h CI Css 45 vs Control	− 6.94 ± 0.05	− 8.16 ± 0.17	− 7.04 ± 0.06
C/T 9 g q24 h CI Css 80 vs Control	–	− 9.81 ± 0.08	− 7.93 ± 0.10

C/T ceftolozane/tazobactam, CI continuous infusion, Css steady-state concentration.

^aLog difference at the end of the assay for each regimen compared with the control.