Table 3.
Thirteen-weeks repeated dose toxicity: hematological values of male dogs (main study) and hematological values of female dogs (main study).
| Summary of hematological tests (sex: male) | ||||
|---|---|---|---|---|
| Main group (mg/kg/day) |
||||
| G1 (0) | G2 (500) | G3 (1000) | G4 (2000) | |
| RBC (^6/μL) | 7.19 ± 0.50 (5) | 7.76 ± 0.29 (3) | 6.44 ± 0.32 (3) | 6.95 ± 0.52 (5) |
| HGB (g/dL) | 16.24 ± 0.84 (5) | 17.77* ± 0.35 (3) | 14.8* ± 0.5 (3) | 15.8 ± 0.83 (5) |
| HCT (%) | 49.16 ± 3.23 (5) | 54.6* ± 1.11 (3) | 45.63 ± 2.01 (3) | 48.22 ± 3.09 (5) |
| MCV (fL) | 68.36 ± 0.9 (5) | 70.33 ± 1.4 (3) | 70.83 ± 1.82 (3) | 69.38 ± 1.11 (5) |
| MCH (pg) | 22.62 ± 0.66 (5) | 22.87 ± 0.55 (3) | 23 ± 0.78 (3) | 22.76 ± 0.68 (5) |
| MCHC (g/dL) | 33.08 ± 0.68 (5) | 32.5 ± 0.66 (3) | 32.47 ± 0.4 (3) | 32.76 ± 0.53 (5) |
| RDW (%) | 1.14 ± 0.21 (5) | 1.11 ± 0.18 (3) | 0.94 ± 0.62 (3) | 1.17 ± 0.42 (5) |
| HDW (g/dL) | 12.86 ± 0.34 (5) | 12.17 ± 0.45 (3) | 12.43 ± 0.21 (3) | 12.58 ± 0.5 (5) |
| RET (%) | 1.56 ± 0.08 (5) | 1.487 ± 0.074 (3) | 1.487 ± 0.122 (3) | 1.494 ± 0.074 (5) |
| PLT (^3/μL) | 267.4 ± 50.6 (5) | 259.3 ± 15.4 (3) | 278.3 ± 75.1 (3) | 342.2 ± 75.3 (5) |
| MPV (fL) | 9.94 ± 0.63 (5) | 9.7 ± 0.72 (3) | 11.07 ± 1.67 (3) | 9.88 ± 0.88 (5) |
| WBC (^3/μL) | 9 ± 0.72 (5) | 10 ± 2.05 (3) | 9.12 ± 0.22 (3) | 10.16 ± 1.90 (5) |
| NEU (%) | 58.18 ± 1.73 (5) | 57.23 ± 3.75 (3) | 51.83 ± 6.4 (3) | 53.72 ± 11.5 (5) |
| LYP (%) | 32.38 ± 2.07 (5) | 33.57 ± 4.83 (3) | 36.5 ± 4.64 (3) | 36.02 ± 8.93 (5) |
| MONO (%) | 5.54 ± 1.12 (5) | 5.93 ± 2.14 (3) | 6.5 ± 0.62 (3) | 6.66 ± 2.61 (5) |
| EOS (%) | 2.92 ± 0.96 (5) | 2.27 ± 0.55 (3) | 3.83 ± 0.67 (3) | 2.42 ± 0.75 (5) |
| BASO (%) | 0.66 ± 0.35 (5) | 0.67 ± 0.21 (3) | 0.73 ± 0.4 (3) | 0.68 ± 0.28 (5) |
| LUC (%) | 0.32 ± 0.18 (5) | 0.3 ± 0.1 (3) | 0.57 ± 0.4 (3) | 0.48 ± 0.26 (5) |
| PT (Seconds) | 5.54 ± 0.4 (5) | 5.73 ± 0.6 (3) | 5.8 ± 0.79 (3) | 5.4 ± 0.29 (5) |
| APTT (Seconds) | 13.84 ± 0.71 (5) | 13.93 ± 0.6 (3) | 12.67* ± 0.12 (3) | 13 ± 0.39 (5) |
| Summary of hematological tests (sex: female) | ||||
|---|---|---|---|---|
| Main group (mg/kg/day) |
||||
| G1 (0) | G2 (500) | G3 (1000) | G4 (2000) | |
| RBC (^6/μL) | 7.35 ± 0.72 (5) | 7.54 ± 0.62(3) | 7.59 ± 0.68(3) | 6.79 ± 0.87(5) |
| HGB (g/dL) | 16.72 ± 1.81 (5) | 16.77 ± 1.82 (3) | 16.9 ± 0.89 (3) | 15.54 ± 2.21 (5) |
| HCT (%) | 51.28 ± 5.85 (5) | 50.7 ± 4.71 (3) | 51.47 ± 3.02 (3) | 47.62 ± 6.62 (5) |
| MCV (fL) | 69.78 ± 2.69 (5) | 67.13 ± 1.16 (3) | 67.93 ± 3.76 (3) | 70.08 ± 1.4 (5) |
| MCH (pg) | 22.78 ± 0.7 (5) | 22.2 ± 0.87 (3) | 22.37 ± 1.66 (3) | 22.89 ± 0.57 (5) |
| MCHC (g/dL) | 32.64 ± 0.54 (5) | 33.07 ± 0.67 (3) | 33.07 ± 0.67 (3) | 32.62 ± 0.22 (5) |
| RDW (%) | 1.11 ± 0.23 (5) | 0.72 ± 0.27 (3) | 0.85 ± 0.29 (3) | 0.68 ± 0.34 (5) |
| HDW (g/dL) | 12.6 ± 0.4 (5) | 12.77 ± 0.4 (5) | 12.07 ± 0.35 (3) | 12.4 ± 0.64 (5) |
| RET (%) | 1.46 ± 0.06 (5) | 1.48 ± 0.03 (3) | 1.49 ± 0.07 (3) | 1.46 ± 0.13 (5) |
| PLT (^3/μL) | 229.2 ± 82.8 (5) | 279.3 ± 38 (3) | 283.3 ± 36.7 (3) | 907.8 ± 75.2 (5) |
| MPV (fL) | 10.42 ± 1.63 (5) | 9.7 ± 0.26 (3) | 9.27 ± 0.49 (3) | 10.66 ± 1.18 (5) |
| WBC (^3/μL) | 9.85 ± 1.9 (5) | 8.45 ± 2.02 (3) | 7.7 ± 1.66 (3) | 9.22 ± 1.39 (5) |
| NEU (%) | 55.52 ± 7.75 (5) | 58.3 ± 6.97 (3) | 56.77 ± 7.32 (3) | 57.92 ± 4.39 (5) |
| LYP (%) | 31.64 ± 2.63 (5) | 33.2 ± 5.27 (3) | 34.57 ± 4.77 (3) | 33.64 ± 3.98 (5) |
| MONO (%) | 5.6 ± 1.51 (5) | 5.07 ± 1.16 (3) | 5.2 ± 1.99 (3) | 5.62 ± 0.69 (5) |
| EOS (%) | 6.12 ± 5.94 (5) | 0.42 ± 0.05 (3) | 2.2 ± 1.04 (3) | 1.56 ± 0.51 (5) |
| BASO (%) | 0.68 ± 0.25 (5) | 2.2 ± 1.04 (3) | 0.7 ± 0.26 (3) | 0.68 ± 0.48 (5) |
| LUC (%) | 0.36 ± 0.15 (5) | 0.18 ± 0.08 (3) | 0.5 ± 0.26 (3) | 0.64 ± 0.18 (5) |
| PT (Seconds) | 5.16 ± 0.35 (5) | 5.27 ± 0.15 (3) | 5.27 ± 0.15 (3) | 5.32 ± 0.32 (5) |
| APTT (Seconds) | 13.78 ± 1.64 (5) | 14.23 ± 0.55 (3) | 14.23 ± 0.55 (3) | 13.36 ± 1.04 (5) |
Mean ± SD (Number of animals). Significant difference compared with the control group value: *P < 0.05.
RBC: Red blood cell, HGB: Hemoglobin, HCT: Hematocrit, MCV: Mean corpuscular volume, MCH: Mean corpuscular hemoglobin, MCHC: Mean corpuscular hemoglobin con- centration, RDW: Red cell distribution width, HDW: Hemoglobin distribution width, RET: Reticulocyte, PLT: Platelet, MPV: Mean platelet volume, WBC: White blood cell, NEU: Neutrophil, LYP: Lymphocyte, MONO: Monocyte, EOS: Eosinophil, BASO: Basophil, LUC: Large unstained cell, PT: Prothrombin time, APTT: Activated partial thromboplastin time.