Table 2.
Top ten up-regulated genes at p-values of < 0.001 and a fold change of > 4.
| ID | Gene Symbol | Chromo-some | Group | p-values | Fold Change |
|---|---|---|---|---|---|
| A. SCD patients in steady-state compared to healthy controls | |||||
| TC0100015815.hg.1 | THEM5 | chr1 | Coding | 9.26E−09 | 126.94 |
| TC0400012018.hg.1 | GYPB | chr4 | Multiple_Complex | 5.24E−11 | 101.13 |
| TC1000008399.hg.1 | IFIT1B | chr10 | Coding | 1.70E−09 | 70.57 |
| TC0100011325.hg.1 | TMCC2 | chr1 | Multiple_Complex | 2.54E−12 | 70.46 |
| TC0Y00006730.hg.1 | EIF1AY | chrY | Multiple_Complex | 1.04E−05 | 69.74 |
| TC0700009232.hg.1 | BPGM | chr7 | Coding | 6.30E−16 | 66.21 |
| TC1400008056.hg.1 | IFI27 | chr14 | Multiple_Complex | 1.70E−06 | 54.87 |
| TC0100017118.hg.1 | YOD1 | chr1 | Multiple_Complex | 6.08E−11 | 50.36 |
| TC1200008726.hg.1 | TCP11L2 | chr12 | Multiple_Complex | 3.47E−12 | 49.56 |
| TC0600007006.hg.1 | RNF182 | chr6 | Coding | 9.59E−05 | 45.94 |
| B. SCD patients in VOC compared to healthy controls | |||||
| TC1000008399.hg.1 | IFIT1B | chr10 | Coding | 3.65E−10 | 313.47 |
| TC1400008056.hg.1 | IFI27 | chr14 | Multiple_Complex | 6.24E−07 | 255.9 |
| TC0Y00006730.hg.1 | EIF1AY | chrY | Multiple_Complex | 4.66E−05 | 211.92 |
| TC0100013223.hg.1 | RAP1GAP | chr1 | Multiple_Complex | 3.56E−05 | 105.06 |
| TC0900010959.hg.1 | HEMGN | chr9 | Multiple_Complex | 3.99E−11 | 90.78 |
| TC0700009232.hg.1 | BPGM | chr7 | Coding | 8.49E−15 | 86.56 |
| TC1800006889.hg.1 | RIOK3 | chr18 | Multiple_Complex | 1.88E−14 | 80.18 |
| TC0100017118.hg.1 | YOD1 | chr1 | Multiple_Complex | 9.70E−11 | 79.84 |
| TC1300008424.hg.1 | USP12 | chr13 | Multiple_Complex | 5.42E−11 | 75.5 |
| TC0400012018.hg.1 | GYPB | chr4 | Multiple_Complex | 2.86E−09 | 68.5 |