Fig. 4. Adults treated with thrice-weekly (R,S)-ketamine or daily (2R,6R)-hydroxynorketamine have impaired novel object recognition later in adulthood.

A Locomotor activity during the habituation phase of the novel object-recognition task (i.e., in the absence of objects) plotted as 5-min time bins (left) and summarized as total distance traveled over the total 30 min (right). B Total time spent exploring two identical objects during the 30 min of training. C Time spent exploring the familiar object and the novel object across the 10 min of testing. D Total time spent exploring the familiar object and the novel object during the 10 min of testing and (E) plotted as a discrimination index (right): (novel-familiar)/(novel + familiar). Data are presented as mean ± standard error of the mean. **P < 0.01, ***P < 0.001.