Fig. 6. Daily (2R,6R)-hydroxynorketamine treatment impairs implicit memory in the passive-avoidance task while thrice-weekly treatment tends to improve it.

A Latency to cross into the dark shock-paired chamber during testing. Mice that did not cross during the 10-min procedure (latency = 600 sec) display (B) “complete” passive avoidance, defined as a failure to cross within 600 s. C Drug exposure led to a shift in the cumulative fraction of scores with regard to latency to cross; corresponding values represent the number of animals that did not cross within each condition (n/N), the percentage of animals that did not cross within each condition (%), and the 50th percentile of scores within each condition (0.5). Data are presented as mean ± standard error of the mean. ***P < 0.001.