TABLE 1.
Participant characteristics
| Heteroplasmy load ≤3 | Heteroplasmy load >3 | |||||
|---|---|---|---|---|---|---|
| Overall (n = 230) |
High mtDNA‐CN (n = 71) |
Low mtDNA‐CN (n = 75) |
High mtDNA‐CN (n = 44) |
Low mtDNA‐CN (n = 40) |
||
|
Mean ± standard deviation or N (%) |
range | Mean ± standard deviation or N (%) | Mean ± standard deviation or N (%) | Mean ± standard deviation or N (%) | Mean ± standard deviation or N (%) | |
| Age, years | 74.7 ± 9.8 | 50 – 93 | 71.3 ± 9.1 | 75.2 ± 9.9 | 75.5 ± 9.8 | 78.7 ± 9.6 |
| Women | 121 (53) | ‐ | 53 (75) | 27 (36) | 27 (61) | 14 (35) |
| Body mass index, kg/m2 | 26.2 ± 4.3 | 17.1–42.9 | 26.6 ± 4.1 | 26.9 ± 4.9 | 24.8 ± 3.8 | 25.9 ± 3.5 |
| 6‐meter usual gait speed, m/s | 1.20 ± 0.20 | 0.63–1.81 | 1.23 ± 0.19 | 1.20 ± 0.19 | 1.21 ± 0.23 | 1.15 ± 0.21 |
| Any cancer | 97 (42) | ‐ | 27 (39) | 37 (49) | 13 (30) | 20 (53) |
| Non‐skin cancer | 26 (11) | ‐ | 4 (6) | 9 (12) | 7 (16) | 6 (15) |
| Diabetes | 11 (5) | 2 (3) | 5 (7) | 2 (5) | 2 (5) | |
| Current or former smokers | 6 (3) | ‐ | 3 (4) | 1 (1) | 1 (2) | 1 (3) |
| High physical activity category (≥150 min/week) | 63 (27) | ‐ | 21 (30) | 18 (24) | 14 (32) | 10 (25) |
| τPCr | 49.4 ± 10.4 | 22.6 – 3.8 | 49.4 ± 10.0 | 48.8 ± 10.1 | 46.2 ± 10.6 | 54.1 ± 10.2 |
| PCr depletion, % | 59.3 ± 10.2 | 33.1–91.0 | 59 ± 10 | 59 ± 11 | 59 ± 10 | 59 ± 10 |
| mtDNA‐CN | 219 ± 42 | 127–366 | 250 ± 29 | 188 ± 18 | 257 ± 34 | 181 ± 23 |
| Heteroplasmy load | Median (IQR) | range | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) |
| 3 (2) | 1–96 | 2 (1) | 2 (1) | 5 (2) | 5 (3) | |